Original paper
Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma
Volume: 366, Issue: 23, Pages: 2171 - 2179
Published: Jun 7, 2012
Abstract
Alterations in hedgehog signaling are implicated in the pathogenesis of basal-cell carcinoma. Although most basal-cell carcinomas are treated surgically, no effective therapy exists for locally advanced or metastatic basal-cell carcinoma. A phase 1 study of vismodegib (GDC-0449), a first-in-class, small-molecule inhibitor of the hedgehog pathway, showed a 58% response rate among patients with advanced basal-cell carcinoma.In this multicenter,...
Paper Details
Title
Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma
Published Date
Jun 7, 2012
Volume
366
Issue
23
Pages
2171 - 2179
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Notes
History