Original paper
Inhibition of murine hepatic cytochrome P450 activities by natural and synthetic phenolic compounds
Abstract
1. The effect of the phenolic compounds protocatechuic acid, chlorogenic acid, tannic acid, gallates and silybin on ethoxyresorufin O-dealkylase (CYP1A1), methoxyresorufin O-dealkylase (CYP1A2) and pentoxy-O-dealkylase (CYP2B) was examined in mouse liver microsomes from induced animals. 2. All compounds tested could inhibit cytochrome P450-mediated enzyme activities, but to different extents. Tannic acid was the most potent inhibitor, especially...
Paper Details
Title
Inhibition of murine hepatic cytochrome P450 activities by natural and synthetic phenolic compounds
Published Date
Jan 1, 1998
Journal
Volume
28
Issue
8
Pages
735 - 743
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Notes
History