Original paper

Structure of West Nile Virus NS3 Protease: Ligand Stabilization of the Catalytic Conformation

Volume: 385, Issue: 5, Pages: 1568 - 1577
Published: Feb 1, 2009
Abstract
Over the last decade, West Nile virus has spread rapidly via mosquito transmission from infected migratory birds to humans. One potential therapeutic approach to treating infection is to inhibit the virally encoded serine protease that is essential for viral replication. Here we report the crystal structure of the viral NS3 protease tethered to its essential NS2B cofactor and bound to a potent substrate-based tripeptide inhibitor,...
Paper Details
Title
Structure of West Nile Virus NS3 Protease: Ligand Stabilization of the Catalytic Conformation
Published Date
Feb 1, 2009
Volume
385
Issue
5
Pages
1568 - 1577
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