Sustained Release Liquid Preparation Using Sodium Alginate for Eradication of Helicobacter pyroli.
Abstract
We prepared a new liquid preparation for eradication of Helicobacter pylori (HP), and examined drug release in vitro and in vivo. The liquid preparation mainly consisted of a sodium alginate (AG) aqueous solution containing ampicillin (ABPC), an antibiotic drug, or methylene blue, a dye. Drug release was retarded by Ca pre-treatment (0.10 M, 20 s) of the AG preparation in in vitro drug release studies due to gel-formation at the liquid surface....
Paper Details
Title
Sustained Release Liquid Preparation Using Sodium Alginate for Eradication of Helicobacter pyroli.
Published Date
Jan 1, 1999
Volume
22
Issue
1
Pages
55 - 60
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