C-jun N-terminal kinase regulates the interaction between 14-3-3 and Bad in ethanol-induced cell death

Activation of the c‐jun N‐terminal kinase (JNK) is known to be an important step during ethanol‐induced cell death, but it has yet to be identified how JNK regulates apoptosis. Therefore, we investigated the mechanism by which JNK induces cell death following ethanol treatment. Ethanol (6 g/kg, 20% in saline) was administered subcutaneously to postnatal 7 day rat pups. Twelve hours after the first ethanol administration, rat pups were...