Jae Yoon Han
Gyeongsang National University
Publications 10
#1N.-Y. Kim (Gyeongsang National University)H-Index: 48
#2Jae Cheal Yoo (Gyeongsang National University)H-Index: 8
Last.Wan Sung Choi (Gyeongsang National University)H-Index: 30
view all 14 authors...
Clusterin (CLU), a glycoprotein, is involved in apoptosis, producing two alternatively spliced isoforms in various cell types. The pro-apoptotic CLU appears to be a nuclear isoform (nuclear clusterin; nCLU), and the secretory CLU (sCLU) is thought to be anti-apoptotic. The detailed molecular mechanism of nCLU as a pro-apoptotic molecule has not yet been clear. In the current study, overexpressed nCLU induced apoptosis in human kidney cells. Biochemical studies revealed that nCLU sequestered Bcl-...
25 CitationsSource
#1Yu Ji ChoH-Index: 10
#2Jae Yoon HanH-Index: 8
Last.Jong Deog LeeH-Index: 9
view all 8 authors...
Angiogenic factors such as vascular endothelial growth factor (VEGF) are implicated in pulmonary hypertension (PH). However, the pathway of angiogenic factor-mediated pathologic angiogenesis in PH remains unclear. In this study, we evaluated the temporal expression of angiopoietin (Ang) 1, Ang2, and their receptor (Tie2) as well as VEGF, endothelial nitric oxide synthase (eNOS), inducible NOS (iNOS), and heme oxygenase 1 (HO1) in the monocrotaline-induced PH model. Histologic evaluation showed p...
15 Citations
#1Ji Yeong Lee (Gyeongsang National University)H-Index: 2
#2Beong Tak Jeon (Gyeongsang National University)H-Index: 1
Last.Gu Seob Roh (Gyeongsang National University)H-Index: 23
view all 10 authors...
Kainic acid (KA)-induced seizure induces the hippocampal cell death. There are reports that AMP-activated protein kinase (AMPK), which is an important regulator of energy homeostasis of cells, has been proposed as apoptotic molecule. In this study, we investigated the altered expression of AMPK cascade in the hippocampus of mice during KA-induced hippocampal cell death. Mice were killed at 2, 6, 24 or 48 h after KA (30 mg/kg) injection. Histological evaluation of KA-treated hippocampus revealed ...
19 CitationsSource
#1Jae Yoon Han (Gyeongsang National University)H-Index: 8
#2Eun Young Jeong (Gyeongsang National University)H-Index: 5
Last.Wan Sung Choi (Gyeongsang National University)H-Index: 30
view all 8 authors...
Activation of the c-jun N-terminal kinase (JNK) is known to be an important step during ethanol-induced cell death, but it has yet to be identified how JNK regulates apoptosis. Therefore, we investigated the mechanism by which JNK induces cell death following ethanol treatment. Ethanol (6 g/kg, 20% in saline) was administered subcutaneously to postnatal 7 day rat pups. Twelve hours after the first ethanol administration, rat pups were decapitated, and extracts of total protein from cerebral cort...
24 CitationsSource
#1Bo Mi Ku (Gyeongsang National University)H-Index: 7
#2Yeon Kyung Lee (Gyeongsang National University)H-Index: 9
Last.Sang Soo Kang (Gyeongsang National University)H-Index: 30
view all 11 authors...
It has been known that ethanol causes neuronal cell death through oxidative stress. Ethanol itself and reactive oxygen species (ROS) produced by ethanol modulate intracellular signaling pathways including mitogen-activated protein kinase (MAPK) cascades. This study was conducted to examine the impact of ethanol on MAPK signaling in HT22 cells. Ethanol (100 and 400 mM) caused activation of ERK, p38 MAPK, and JNK. ERK activation occurred in early time and p38 MAPK activation was evident when ERK a...
49 CitationsSource
#1Hae Sook Noh (Gyeongsang National University)H-Index: 19
#2Yoon Sook Kim (Gyeongsang National University)H-Index: 13
Last.Wan Sung Choi (Gyeongsang National University)H-Index: 30
view all 10 authors...
The ketogenic diet (KD) is often effective for intractable epilepsy, but its antiepileptic mechanisms remain largely unknown. Within the cell death/survival pathway, Akt and its downstream protein Bad play an important role in kainic acid (KA)-induced cell death. Therefore, we investigated the effects of a KD on KA-induced changes in the Akt/Bad/14-3-3 signaling pathway by evaluating Akt, Bad, 14-3-3, and cleaved caspase-3 expression levels as well as their relative interactions. Our results sho...
36 CitationsSource
#1Hyun Joon Kim (Gyeongsang National University)H-Index: 23
#2Kyung Mi Choi (Gyeongsang National University)H-Index: 2
Last.Wan Sung Choi (Gyeongsang National University)H-Index: 30
view all 11 authors...
Abstract Acute alcohol ingestion is well known to have deleterious effects on memory and also known to inhibit long-term potentiation, a putative cellular substrate of memory. In this study, we for the first time revealed that growth-associated protein 43 (GAP-43), which is well known as a presynaptic substrate of protein kinase C and one of the major synaptic plasticity-related genes, was down regulated by single ethanol administration (2.5 g/kg, 15% in saline, i.p.) in the rat hippocampus. Usi...
6 CitationsSource
#1Jae Yoon Han (Gyeongsang National University)H-Index: 8
#2Joo Yeon Jeong (Gyeongsang National University)H-Index: 9
Last.Wan Sung Choi (Gyeongsang National University)H-Index: 30
view all 8 authors...
Abstract Administration of ethanol to immature rat pups during the period in which synaptogenesis occurs triggers extensive apoptotic cell death in the brain. This ethanol-induced cell death is known to be mediated by Bax activation, which is caused by mitochondrial dysfunction. However, little data is available regarding the regulation of survival signaling pathways and their downstream events that lead to Bax activation. Thus, in the present study, we aimed to investigate the effect of ethanol...
23 CitationsSource
#1Hae Sook Noh (Gyeongsang National University)H-Index: 19
#2Sang Soo Kang (Gyeongsang National University)H-Index: 30
Last.Wan Sung Choi (Gyeongsang National University)H-Index: 30
view all 8 authors...
Abstract The ketogenic diet (KD) increased the expression of calbindin-D 28k (CB) in the interneurons of the hippocampus compared with the normal diet (ND)-fed mice. Also, 2 days after kainic acid (KA) administration, numerous CB-expressing astrocytes were found in the KD-fed mice compared with those of the ND-fed mice. These results suggest that the neuroprotective effect of the KD on the KA-induced toxicity may be, in part, mediated via an increased expression of CB.
21 CitationsSource
#1Hyun Joon Kim (Gyeongsang National University)H-Index: 23
#2Hyun Joon SohnH-Index: 1
Last.Gyeong Jae Cho (Gyeongsang National University)H-Index: 30
view all 7 authors...
We found that prolonged administration of ethanol (3 g/kg i.p. at 08:00, once per day) to young female rats starting on postnatal day 24 caused delayed puberty. We further found that prolonged ethanol administration changed the typical hypothalamic expression patterns of TTF-1 and Oct-2 and reduced GnRH mRNA expression. We suggest that these changes may cause the ethanol-induced disturbances in the regulation of GnRH in the hypothalamus and may be responsible for the ethanol-induced reduction in...
8 CitationsSource