Synthesis, characterization, and antitumor activity of new platinum(IV) trans-carboxylate complexes: Crystal structure of [Pt(cis-1,4-DACH)trans-(acetate)2Cl2]

A series of novel platinum(IV) cisplatin analogues of the type [Pt(cis-1,4-DACH)trans-(L)2Cl2] (where cis-1,4-DACH=cis-1,4-diaminocyclohexane and L=acetate, propionate, butyrate, valerate, hexanoate, heptanoate, octanoate, nonanoate, or decanoate) was synthesized and characterized by elemental analysis, IR, 13C-NMR, and 195Pt-NMR spectroscopy. The structure of [Pt(cis-1,4-DACH)trans-(acetate)2Cl2] (1) was determined by X-ray crystallography. The...