Genetic Risk Factors for Type 2 Diabetes: A Trans-Regulatory Genetic Architecture?
Abstract
To date, 68 loci have been associated with type 2 diabetes (T2D) or glucose homeostasis traits. We report here the results of experiments aimed at functionally characterizing the SNPs replicated for T2D and glucose traits. We sought to determine whether these loci were associated with transcript levels in adipose, muscle, liver, lymphocytes, and pancreatic β-cells. We found an excess of trans, rather than cis, associations among these SNPs in...
Paper Details
Title
Genetic Risk Factors for Type 2 Diabetes: A Trans-Regulatory Genetic Architecture?
Published Date
Sep 1, 2012
Volume
91
Issue
3
Pages
466 - 477
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