Cardiac SERCA2A/B: Therapeutic targets for heart failure
Abstract
Calcium (Ca2+) recycling is key for effective relaxation of the cardiac muscle. Failure to properly recycle calcium through the sarcoplasmic reticulum (SR) results in severe impairment of myocardial relaxation and consequently alteration of the “beat-to-beat” heart rhythm and contractile function. The Sarco(Endo)plasmic reticulum Ca2+ ATPase (SERCA) is instrumental for recycling cytosolic Ca2+ into the lumen of the SR. Among the many SERCA...
Paper Details
Title
Cardiac SERCA2A/B: Therapeutic targets for heart failure
Published Date
Feb 1, 2014
Volume
724
Pages
1 - 8
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