European Journal of Pharmacology
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#1Yuanyuan Zhou (Zhengzhou University)H-Index: 1
#2Junhong Zhang (Zhengzhou University)H-Index: 1
Last. Hang Zhang (Zhengzhou University)
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Abstract P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) remains a significant impediment to the success of cancer chemotherapy. The natural flavonoid Quercetin (Que) has been reported to be able to inhibit P-gp-mediated MDR in various cancer cells. However, the MDR reversal effect of Que on human colon cancer cells and its mechanism at the metabolic level requires further clarification. This study was designed to provide a better understanding of the MDR reversal effect of Que. Our pr...
#1Mohammad HashemiH-Index: 30
#2Sajjad Aftabi (UM: University of Manitoba)
Last. Saeid Ghavami (UM: University of Manitoba)H-Index: 35
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: Caspase-8 plays is an essential enzyme in apoptosis pathway. Several investigation have been done to identify the relation between CASP8 polymorphisms and different human cancers, but, the findings are still debated. The aim of the current investigation is to assess if CASP8 rs3834129 (-652 6N insertion/deletion), rs1045485 G > C, rs3769818 G > A, rs6723097 A > C, rs3769821 T > C, rs13113 T > A, rs3769825 G > A, rs2293554 A > C, and rs10931936 C > T polymorphisms are linked to susceptibility o...
#1Anand P. GuptaH-Index: 4
#2Richa Garg (AcSIR: Academy of Scientific and Innovative Research)
Last. Jiaur R. GayenH-Index: 18
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: Pancreastatin (PST), a chromogranin A (CHGA) derived peptide connects obesity with insulin resistance by inducing inflammation. Previously, we have evaluated potential activity of PST inhibitor (PSTi8) in liver and adipose tissue in type 2 diabetic mice model. In this study we further explore the therapeutic effect of PSTi8 on glucose metabolism in skeletal muscle cells/tissue and its effect on energy homeostasis in diet induced diabetic mice model. In in-vitro studies, we found that PSTi8 inc...
#1Yujia Liang (Guangxi Medical University)
#2Rui Zhou (Guangxi Medical University)H-Index: 3
Last. Bin Yang (Guangxi Medical University)H-Index: 5
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Abstract Plumbagin (PL) pharmacologically plays the anti-proliferative effects in cancer cells, including effective suppression of colorectal cancer (CRC). However, the exact molecular mechanism of PL to treat CRC remains unclear. Using available SwissTargetPrediction and SuperPred databases, the anti-cancer biotargets of PL were identified, and the CRC-diseased targets were obtained through a DisGeNET database. The biological processes, and signaling pathways of PL to treat CRC were identified ...
: The effects of anaesthetic agents on brain energy metabolism may explain their shared neurophysiological actions but remain poorly understood. The brain lactate shuttle hypothesis proposes that lactate, provided by astrocytes, is an important neuronal energy substrate. Here we tested the hypothesis that anaesthetic agents impair the brain lactate shuttle by interfering with astrocytic glycolysis. Lactate biosensors were used to record changes in lactate release by adult rat brainstem and corti...
#1Glauber Ruda Braz (UFPE: Federal University of Pernambuco)H-Index: 6
#2Severina Cassia de Andrade Silva (UFPE: Federal University of Pernambuco)H-Index: 3
Last. Claudia Jacques Lagranha (UFPE: Federal University of Pernambuco)H-Index: 9
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: Nutritional imbalance in early life may disrupt the hypothalamic control of energy homeostasis and increase the risk of metabolic disease. The hypothalamic serotonin (5-hydroxytryptamine; 5-HT) system based in the hypothalamus plays an important role in the homeostatic control of energy balance, however the mechanisms underlying the regulation of energy metabolism by 5-HT remain poorly described. Several crucial mitochondrial functions are altered by mitochondrial stress. Adaptations to this s...
#1Lian-kuai Chen (JNU: Jinan University)
#2Jialong Cai (JNU: Jinan University)H-Index: 2
Last. Xiaoping Wu (JNU: Jinan University)H-Index: 12
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Abstract Prostate cancer (PCa) is the most common malignancy among men. Tumor metastasis and chemoresistance contribute to the major cause of the mortality. In this study, we compared the protein profiles of two prostate cancer cell lines with different metastatic potentials, and identified cofilin-1 (CFL1) was one of the most differentially expressed proteins between two cell lines. Further results suggested that cofilin-1 promoted the remodeling of F-actin cytoskeleton, and enhanced the prolif...
#1Ann-Kathrin Rahm (University Hospital Heidelberg)H-Index: 7
#2Mara Elena Müller (Heidelberg University)
Last. Tanja Heimberger (University Hospital Heidelberg)
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Transient outward K(+) current, Ito, contributes to cardiac action potential generation and is primarily carried by Kv4.3 (KCND3) channels. Two Kv4.3 isoforms are expressed in human ventricle and show differential remodeling in heart failure (HF). Lidocaine and mexiletine may be applied in selected patients to suppress ventricular arrhythmias, without effects on sudden cardiac death or mortality. Isoform-dependent effects of antiarrhythmic drugs on Kv4.3 channels and potential implications for r...
#2Temidayo Olutayo Omobowale (UI: University of Ibadan)H-Index: 9
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: Hypertension is a condition with chronic elevation of blood pressure and a common preventable risk factor for cardiovascular disease with attendant global morbidity and mortality. The present study investigated the novel antihypertensive and neuroprotective effect of Naringenin on L-NG-Nitro arginine methyl ester (L-NAME) induced hypertension together with possible molecular mechanism of action. Rats were divided into four groups. Rats in Group A were normotensive. The hypertensive group (Grou...
#1Harun Un (Ağrı İbrahim Çeçen University)H-Index: 5
#2Rustem Anil Ugan (Atatürk University)H-Index: 5
Last. Zekai Halici (Atatürk University)H-Index: 25
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Abstract Cisplatin is widely used chemotherapeutic drug and have some serious side effects as tissue toxicity and nausea and vomiting. Aprepitant is used in clinic as an anti-emetic drug for cisplatin treated patient to prevent nausea and vomiting. We aimed to investigate the protective effects of Aprepitant on cisplatin-induced nephrotoxicity and hepatotoxicity. In total 42 male rats were separated into six groups (n = 7). A single dose of cisplatin (10 mg/kg i.p.) was administered to induce to...
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