N-acetylcysteine-induced vasodilation involves voltage-gated potassium channels in rat aorta

N-acetylcysteine (NAC) has a protective effect against vascular dysfunction by decreasing the level of reactive oxygen species (ROS) in experimental and human hypertension. This study was designed to examine whether NAC would relax vascular rings in vitro via nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway, extracellular Ca2+ and/or K+ channels.Rat aortic arteries were mounted in an organ bath, contracted with 0.1, 0.5 or 1...