A Mechanism for Fatty Acid Inhibition of Glucose Utilization in Liver

The glucose-stimulated rise in Fru-2,6-P2 in liver results from xylulose 5-P activation of a specific protein phosphatase 2A which dephosphorylates Fru-6-P,2-kinase:Fru-2,6-bisphosphatase (Nishimura, M., and Uyeda, K. (1994) J. Biol. Chem. 269, 26100-26106). In order to determine the role of xylulose 5-P in regulating Fru-2,6-P2 in liver, the effect of fatty acids, various hexoses, and hormones was examined in perfused rat liver and in intact...