Protein Kinase A (PknA) of Mycobacterium tuberculosis Is Independently Activated and Is Critical for Growth in Vitro and Survival of the Pathogen in the Host

Background: Protein kinase A has been shown to be involved in modulating critical functions.Results: Although the activity of PknA is crucial for cell growth, the extracellular domain is expendable.Conclusion: Although the activation of PknA is necessary for its function, this is independent of PknB.Significance: PknA plays an indispensable role and is required for both in vitro and in vivo growth.The essential mycobacterial protein kinases PknA...