Original paper
AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC
Abstract
Inflammasomes are protein complexes assembled upon recognition of infection or cell damage signals, and serve as platforms for clustering and activation of procaspase-1. Oligomerisation of initiating proteins such as AIM2 (absent in melanoma-2) and NLRP3 (NOD-like receptor family, pyrin domain-containing-3) recruits procaspase-1 via the inflammasome adapter molecule ASC (apoptosis-associated speck-like protein containing a CARD). Active...
Paper Details
Title
AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC
Published Date
May 3, 2013
Volume
20
Issue
9
Pages
1149 - 1160
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Notes
History