Cell Death & Differentiation
Papers 4644
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#1Yifan Xie (Fudan University)H-Index: 1
#2Yang Gao (Fudan University)H-Index: 1
Last. Ge Junbo (Fudan University)H-Index: 44
view all 9 authors...
Pathological cardiac hypertrophy eventually leads to heart failure without adequate treatment. REGγ is emerging as 11S proteasome activator of 20S proteasome to promote the degradation of cellular proteins in a ubiquitin- and ATP-independent manner. Here, we found that REGγ was significantly upregulated in the transverse aortic constriction (TAC)-induced hypertrophic hearts and angiotensin II (Ang II)-treated cardiomyocytes. REGγ deficiency ameliorated pressure overload-induced cardiac hypertrop...
#1Sunsook Hwang (SNU: Seoul National University)H-Index: 4
#2Changjin Lee (SNU: Seoul National University)H-Index: 12
Last. Masanobu Satake (Tohoku University)H-Index: 30
view all 13 authors...
CD4/CD8 T-cell lineage differentiation is a key process in immune system development; however, a defined regulator(s) that converts the signal from T-cell receptor and co-receptor complexes into lineage differentiation remains unclear. Here, we show that Twist2 is a critical factor in CD4/CD8 thymocyte differentiation. Twist2 expression is differentially regulated by T-cell receptor signaling, leading to differentiation into the CD4 or CD8 lineage. Forced Twist2 expression perturbed CD4+ thymocy...
#1Jun-Tao Lu (TMUCIH: Tianjin Medical University Cancer Institute and Hospital)H-Index: 1
#2Cong-Cong Tan (TMUCIH: Tianjin Medical University Cancer Institute and Hospital)
Last. Yu-Mei Feng (TMUCIH: Tianjin Medical University Cancer Institute and Hospital)H-Index: 1
view all 9 authors...
The mesenchymal transcription factor forkhead box F2 (FOXF2) is a critical regulator of embryogenesis and tissue homeostasis. Our previous studies demonstrated that FOXF2 is ectopically expressed in basal-like breast cancer (BLBC) cells and that FOXF2 deficiency promotes the epithelial–mesenchymal transition and aggressiveness of BLBC cells. In this study, we found that FOXF2 controls transforming growth factor-beta (TGF-β)/SMAD signaling pathway activation through transrepression of TGF-β-codin...
#1Hua Yu (CAS: Chinese Academy of Sciences)H-Index: 2
#2Jun Ding (SJTU: Shanghai Jiao Tong University)H-Index: 9
Last. X. C. Wang (CAS: Chinese Academy of Sciences)H-Index: 11
view all 9 authors...
The lysyl oxidase (LOX) family is closely related to the progression of glioma. To ensure the clinical significance of LOX family in glioma, The Cancer Genome Atlas (TCGA) database was mined and the analysis indicated that higher LOXL1 expression was correlated with more malignant glioma progression. The functions of LOXL1 in promoting glioma cell survival and inhibiting apoptosis were studied by gain- and loss-of-function experiments in cells and animals. LOXL1 was found to exhibit antiapoptoti...
#1Soumyadip Das (Hanyang University)H-Index: 2
#2Arun Pandian Chandrasekaran (Hanyang University)H-Index: 2
Last. Hyongbum KimH-Index: 16
view all 12 authors...
Conventional screening methods for deubiquitinating enzymes (DUBs) have important limitations. A loss-of-function study based on the knockout of DUB genes in mammalian cells can provide an excellent model for exploring DUB function. Here, we used CRISPR-Cas9 to perform genome-scale knockout of the entire set of genes encoding ubiquitin-specific proteases (USPs), a DUB subfamily, and then systematically screened for DUBs that stabilize the Cdc25A oncoprotein. USP3 was identified as a deubiquitina...
#1Valentina Sladky (Innsbruck Medical University)H-Index: 3
#2Andreas Villunger (Austrian Academy of Sciences)H-Index: 52
The PIDDosome is a multiprotein complex that drives activation of caspase-2, an endopeptidase originally implicated in apoptosis. Yet, unlike other caspases involved in cell death and inflammation, caspase-2 seems to exert additional versatile functions unrelated to cell death. These emerging roles range from control of transcription factor activity to ploidy surveillance. Thus, caspase-2 and the PIDDosome act as a critical regulatory unit controlling cellular differentiation processes during or...
#1Mandi Gandelman (UofU: University of Utah)H-Index: 1
#2Warunee Dansithong (UofU: University of Utah)H-Index: 13
Last. Stefan M. Pulst (UofU: University of Utah)H-Index: 54
view all 6 authors...
Staufen-1 (STAU1) is an RNA-binding protein that becomes highly overabundant in numerous neurodegenerative disease models, including those carrying mutations in presenilin1 (PSEN1), microtubule-associated protein tau (MAPT), huntingtin (HTT), TAR DNA-binding protein-43 gene (TARDBP), or C9orf72. We previously reported that elevations in STAU1 determine autophagy defects and its knockdown is protective in models of several neurodegenerative diseases. Additional functional consequences of STAU1 ov...
#1Plamena R. AngelovaH-Index: 22
#2Minee L. Choi (Francis Crick Institute)H-Index: 6
Last. Karamjit Singh Dolt (Edin.: University of Edinburgh)H-Index: 3
view all 19 authors...
#1Alessio Reggio (University of Rome Tor Vergata)H-Index: 1
#2Marco Rosina (University of Rome Tor Vergata)H-Index: 1
Last. Mauro CerretaniH-Index: 7
view all 14 authors...
Fibro/Adipogenic Progenitors (FAPs) are muscle-interstitial progenitors mediating pro-myogenic signals that are critical for muscle homeostasis and regeneration. In myopathies, the autocrine/paracrine constraints controlling FAP adipogenesis are released causing fat infiltrates. Here, by combining pharmacological screening, high-dimensional mass cytometry and in silico network modeling with the integration of single-cell/bulk RNA sequencing data, we highlighted the canonical WNT/GSK/β-catenin si...
#1Francesca Castoldi (University of Paris)
#2Mervi T. Hyvönen (University of Eastern Finland)H-Index: 12
Last. Nicolas Signolle (University of Paris-Sud)
view all 25 authors...
The pharmacological targeting of polyamine metabolism is currently under the spotlight for its potential in the prevention and treatment of several age-associated disorders. Here, we report the finding that triethylenetetramine dihydrochloride (TETA), a copper-chelator agent that can be safely administered to patients for the long-term treatment of Wilson disease, exerts therapeutic benefits in animals challenged with hypercaloric dietary regimens. TETA reduced obesity induced by high-fat diet, ...
Top fields of study
Molecular biology
Programmed cell death
Cell biology