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Cell Death & Differentiation
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Papers 4531
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#1Roberto Bravo-Sagua (University of Chile)H-Index: 12
#2Valentina Parra (University of Chile)H-Index: 22
Last.Sergio Lavandero (University of Chile)H-Index: 51
view all 15 authors...
Following publication of the article, the authors wrote to point out the following mistake:
#1Kota FujikiH-Index: 5
#2Hisako InamuraH-Index: 6
Last.Masato MatsuokaH-Index: 20
view all 4 authors...
Various types of cell death, including apoptosis, necrosis, necroptosis, and ferroptosis, are induced in renal tubular epithelial cells following exposure to environmental stresses and toxicants such as osmotic stress, ischemia/reperfusion injury, cisplatin, and cadmium. This is known to cause renal dysfunction, but the cellular events preceding stress-induced cell death in renal tubules are not fully elucidated. The activin receptor-like kinase (ALK) 4/5, also known as activin-transforming grow...
#1Chuan xia Zhang (SYSU: Sun Yat-sen University)H-Index: 2
#2Shu Biao YeH-Index: 8
Last.Jun Cui (SYSU: Sun Yat-sen University)H-Index: 3
view all 13 authors...
Stimulator of interferon genes (STING), a major adaptor protein in antiviral innate immune signaling, is considered as one of the most important regulators of antiviral and antitumor immunity. Although STING agonists are now intensively studied in clinical trials as a new class of adjuvants to boost cancer immunotherapy, the tumor-intrinsic role of the STING pathway in shaping the tumor microenvironment remains controversial. Here, we discovered that STING plays a vital role in regulation of mye...
#1Audrey Mouche (University of Rennes)H-Index: 1
#2Jérôme Archambeau (University of Rennes)H-Index: 1
Last.Rémy Pedeux (University of Rennes)H-Index: 20
view all 8 authors...
Inhibitor of Growth 3 (ING3) is a candidate tumor suppressor gene whose expression is lost in tumors such as hepatocellular carcinoma, head and neck squamous cell carcinoma and melanoma. In the present study, we show that ING3-depleted human cells and yeast cells deleted for its ortholog YNG2 are sensitive to DNA damage suggesting a conserved role in response to such stress. In human cells, ING3 is recruited to DNA double strand breaks and is required for ATM activation. Remarkably, in response ...
#1Jie Liu (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Yanfeng Liu (SJTU: Shanghai Jiao Tong University)
Last.Wei-Qiang Gao (SJTU: Shanghai Jiao Tong University)H-Index: 40
view all 9 authors...
During neocortical development, there are two important events, including expansion of the neural progenitor pool through symmetric divisions, and generation of neurons via asymmetrical divisions that lead to a serial process of neuronal polarization, migration, and layer-type specific phenotype acquisition. The mechanisms underlying these processes remain poorly elucidated. Here, we show that the transcription factor Zeb1 regulates the orientation of the cleavage plane of dividing neural progen...
#1Lei Li (SYSU: Sun Yat-sen University)H-Index: 17
#2Yin Li Zheng (SYSU: Sun Yat-sen University)
Last.Xin-YuanGuanH-Index: 66
view all 9 authors...
Hepatocellular carcinoma (HCC) is one of the most aggressive malignancies and lacks targeted therapies. Here, we reported a novel potential therapeutic target hematological and neurological expressed 1 like (HN1L) in HCC. First, HCC tissue microarray analysis showed that HN1L was frequently up-regulated in cancer tissues than that in normal liver tissues, which significantly associated with tumor size, local invasion, distant metastases, and poor prognosis for HCC patients. Functional studies de...
#1Chenling Meng (CUHK: The Chinese University of Hong Kong)H-Index: 4
#2Jinyue Liao (CUHK: The Chinese University of Hong Kong)H-Index: 5
Last.Yin Xia (CUHK: The Chinese University of Hong Kong)H-Index: 13
view all 9 authors...
Lethal (3) malignant brain tumor like 2 (L3MBTL2) is a member of the MBT-domain proteins, which are involved in transcriptional repression and implicated in chromatin compaction. Our previous study has shown that L3MBTL2 is highly expressed in the testis, but its role in spermatogenesis remains unclear. In the present study, we found that L3MBTL2 was most highly expressed in pachytene spermatocytes within the testis. Germ cell-specific ablation of L3mbtl2 in the testis led to increased abnormal ...
#1Jason E. Long (Genentech)H-Index: 24
#2Matthew Wongchenko (Genentech)H-Index: 12
Last.Melissa R. Junttila (Genentech)H-Index: 13
view all 14 authors...
Emerging research suggests that multiple tumor compartments can influence treatment responsiveness and relapse, yet the search for therapeutic resistance mechanisms remains largely focused on acquired genomic alterations in cancer cells. Here we show how treatment-induced changes occur in multiple tumor compartments during tumor relapse and can reduce benefit of follow-on therapies. By using serial biopsies, next-generation sequencing, and single-cell transcriptomics, we tracked the evolution of...
#1Jialiang Shao (GU: Guangzhou University)H-Index: 1
Last.Xiong-Jun Wang (GU: Guangzhou University)
view all 8 authors...
TP53 is the most frequently mutated gene in human cancer, whereas tumors with wild-type TP53 develop alternative strategies to survive. Identifying new regulators of p53 reactivation would greatly contribute to the development of cancer therapies. After screening the entire genome in liver cancer cells, we identified lysyl oxidase-like 4 (LOXL4) as a novel regulator for p53 activation. We found that 5-azacytidine (5-aza-CR) induces LOXL4 upregulation, with LOXL4 subsequently binding the basic do...
#1Qi Zhang (WHU: Wuhan University)H-Index: 2
#2Ze-Yan Zhang (WHU: Wuhan University)H-Index: 5
Last.Xiao-Dong Zhang (WHU: Wuhan University)H-Index: 9
view all 10 authors...
The transcription factor nuclear factor (erythroid-derived 2)-like 2 (NRF2) is one of the master regulators that control hundreds of genes containing antioxidant response elements (AREs). The NRF2-ARE pathway plays a complex role in colorectal cancer (CRC). NRF2 activity is known to be regulated by KEAP1-CUL3 E3 ligase-mediated ubiquitination, indicating the importance of deubiquitination regulation. However, the deubiquitinase (DUB) of NRF2 remains unknown. Here, by screening a DUB library, we ...
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