Different effects of two cyclic chalcone analogues on cell cycle of Jurkat T cells

It has been previously shown that the cyclic chalcone analogues E-2-(4′-methoxybenzylidene)- (2) and E-2-(4′-methylbenzylidene)-1-benzusuberone (3) inhibited proliferation of various murine and human tumor cells. In order to gain new insights into the cytotoxic mechanism of the two compounds detection of apoptosis and necrosis of Jurkat T cells exposed to 2 and 3 were performed by flow cytometry using the Annexin V-FITC and propidium iodide...