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Toxicology in Vitro
IF
3.07
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5078
Papers 5142
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Newest
Published on Dec 1, 2019in Toxicology in Vitro 3.07
Wonhyoung Park (KU: Korea University), Min Young Park (KU: Korea University)+ 1 AuthorsWhasun Lim15
Estimated H-index: 15
(Kookmin University)
Abstract Mammary gland epithelial cells play a key role in milk production in dairy cattle, which are prone to feed contamination from microorganisms, especially pathogenic fungi and their mycotoxin products. When mycotoxins enter the body, they cause a reduction in feed intake and milk production, leading to the retardation of growth and productivity in dairy cattle. Among them, aflatoxin B1 is a ubiquitous food contaminant frequently found in stored crops, which are used as animal feed, and ca...
Published in Toxicology in Vitro 3.07
Magdalena Zdybel5
Estimated H-index: 5
(Medical University of Silesia),
Ewa Chodurek9
Estimated H-index: 9
(Medical University of Silesia),
Barbara Pilawa15
Estimated H-index: 15
(Medical University of Silesia)
Abstract Malignant melanoma is the most aggressive and lethal form of skin cancer. Therefore the search for new methods of the treatment for melanoma is needed. In this work simvastatin was tested as the substance of potential anticancer activity. The aim of this study was to determine the effect of simvastatin in different concentration on free radicals in A-375 human melanoma malignum cells. Free radicals and growth of A-375 melanoma cells cultured without and with simvastatin were examined. F...
Published in Toxicology in Vitro 3.07
Stewart Lebrun , Yilu Xie7
Estimated H-index: 7
(UCI: University of California, Irvine)
+ -3 AuthorsJames V. Jester63
Estimated H-index: 63
(UCI: University of California, Irvine)
Abstract The purpose of this study was to develop Globally Harmonized System (GHS) and U.S. Environmental Protection Agency (EPA) prediction models for classifying irritant materials based on histopathologic in vitro depth of injury (DoI) measurements. Sixteen different materials were selected, representing all classes of toxicity, according to the GHS and EPA classification systems. Food-source rabbit eyes, similar to eyes used for the widely accepted Bovine Corneal Opacity and Permeability and...
Published on Dec 1, 2019in Toxicology in Vitro 3.07
David M. Brown35
Estimated H-index: 35
(Heriot-Watt University),
Pernille Høgh Danielsen23
Estimated H-index: 23
(UCPH: University of Copenhagen)
+ 6 AuthorsAli Kermanizadeh19
Estimated H-index: 19
(Heriot-Watt University)
Abstract The rapid expansion of the incorporation of nano-sized materials in consumer products overlaps with the necessity for high-throughput reliable screening tools for the identification of the potential hazardous properties of the nanomaterials. The ToxTracker assay (mechanism-based reporter assay based on embryonic stem cells that uses GFP-tagged biomarkers for detection of DNA damage, oxidative stress and general cellular stress) is one such tool, which could prove useful in the field of ...
Published in Toxicology in Vitro 3.07
Yonghong Miao1
Estimated H-index: 1
,
Xiaoxue Sun1
Estimated H-index: 1
(Henan Normal University)
+ -3 AuthorsLiyong Huang5
Estimated H-index: 5
(Xinxiang Medical University)
Abstract (-)-epigallocatechin-3-gallate (EGCG), the main component of green tea, has long been explored in the treatment and/or prevention of central nervous system (CNS) disorders. However, EGCG has been recently shown to exhibit acute and subacute toxicity. Although a lot of work has been done, the mechanisms of EGCG-induced mitochondrial dysfunction has not been delineated in primary astrocyte. Here, the mitotoxic effect of EGCG on primary astrocytes was investigated by measuring Ca2+ overloa...
Published on Dec 1, 2019in Toxicology in Vitro 3.07
Marwa Boussada1
Estimated H-index: 1
(Tunis University),
Ridha Ben Ali4
Estimated H-index: 4
(Tunis University)
+ 6 AuthorsMichèle Véronique El May2
Estimated H-index: 2
(Tunis University)
Abstract Doxorubicin (DOX) exhibits a wide-ranging spectrum of antitumor activities which maintain its clinical use despite its devastating impact on highly proliferating cells. The present work was designed to develop a new approach which aims to protect male germ cells from DOX cytotoxicity. Thus, an assessment of the protective potential of a new thioamide analog (thiocyanoacetamide; TA) compared to selenium (Se) was performed in rat sperms exposed to DOX in vitro . Oxygen consumption rate (O...
Published on Dec 1, 2019in Toxicology in Vitro 3.07
Sophie L. Penman (University of Liverpool), Parveen Sharma15
Estimated H-index: 15
(University of Liverpool)
+ 3 AuthorsAmy E. Chadwick6
Estimated H-index: 6
(University of Liverpool)
Abstract Bile acids (BAs) are recognised as the causative agents of toxicity in drug-induced cholestasis (DIC). Research in isolated mitochondria and HepG2 cells have demonstrated BA-mediated mitochondrial dysfunction as a key mechanism of toxicity in DIC. However, HepG2 cells are of limited suitability for DIC studies as they do not express the necessary physiological characteristics. In this study, the mitotoxic potentials of BA mixtures were assessed in isolated mitochondria and a better-suit...
Published on Jul 1, 2019in Toxicology in Vitro 3.07
Maria Elisa Giuliani8
Estimated H-index: 8
,
Erica Sparaventi + 3 AuthorsStefania Gorbi24
Estimated H-index: 24
Abstract The precision-cut tissue slices (PCTS) represent a largely used biological model in mammalian research. This ex vivo approach offers the main advantages of in vitro systems, while maintaining the natural architecture of the tissue. The use of PCTS in toxicological research has been proposed for investigating the cellular effects of xenobiotics or bioactive compounds mostly in mammalian models. Their application is increasing also in marine organisms, but still limited to fish. This work...
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