Review paper
Mechanisms of Disease: pharmacogenetics of testosterone therapy in hypogonadal men
Abstract
A defective, mutated androgen receptor may lead to variable phenotypes of androgen insensitivity in humans. Also, the CAG repeat polymorphism in exon 1 of the androgen receptor gene modulates androgen effects; in vitro, transcription of androgen-dependent target genes is attenuated with increasing length of triplet residues. Clinically, the CAG repeat polymorphism causes significant modulations of androgenicity in various tissues and...
Paper Details
Title
Mechanisms of Disease: pharmacogenetics of testosterone therapy in hypogonadal men
Published Date
Mar 1, 2007
Volume
4
Issue
3
Pages
161 - 166
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