Original paper
Chromosomal Translocations in Human Cells Are Generated by Canonical Nonhomologous End-Joining
Abstract
Breakpoint junctions of the chromosomal translocations that occur in human cancers display hallmarks of nonhomologous end-joining (NHEJ). In mouse cells, translocations are suppressed by canonical NHEJ (c-NHEJ) components, which include DNA ligase IV (LIG4), and instead arise from alternative NHEJ (alt-NHEJ). Here we used designer nucleases (ZFNs, TALENs, and CRISPR/Cas9) to introduce DSBs on two chromosomes to study translocation joining...
Paper Details
Title
Chromosomal Translocations in Human Cells Are Generated by Canonical Nonhomologous End-Joining
Published Date
Sep 1, 2014
Journal
Volume
55
Issue
6
Pages
829 - 842
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Notes
History