Effect ofS-adenosyl-l-methionine on ethanol cholestasis and hepatotoxicity in isolated perfused rat liver

We investigated whetherS-adenosyl-l-methionine (SAMe) influences the inhibitory effect of ethanol on bile secretion and ethanol hepatotoxicity in the isolated perfused rat liver. SAMe (25 mg/kg intramuscularly three times a day) was administered for three days consecutively. Liver was then isolated and perfused with taurocholate to stabilize bile secretion and exposed to 1% ethanol for 70 min. The effect of ethanol on bile flow, bile salt...