Domenico Alvaro
Sapienza University of Rome
EndocrinologyStem cellDiabetes mellitusMedicineBiology
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Publications 474
#1J-Matthias Löhr (Karolinska University Hospital)H-Index: 8
#2Ulrich Beuers (UvA: University of Amsterdam)H-Index: 59
Last. Emanuel Della-Torre (UniSR: Vita-Salute San Raffaele University)H-Index: 14
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The overall objective of these guidelines is to provide evidence-based recommendations for the diagnosis and management of immunoglobulin G4 (IgG4)-related digestive disease in adults and children. IgG4-related digestive disease can be diagnosed only with a comprehensive work-up that includes histology, organ morphology at imaging, serology, search for other organ involvement, and response to glucocorticoid treatment. Indications for treatment are symptomatic patients with obstructive jaundice, ...
#1Guido Carpino (Sapienza University of Rome)H-Index: 38
#2M. Del Ben (Sapienza University of Rome)H-Index: 25
Last. Francesco Violi (Sapienza University of Rome)H-Index: 62
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Lipopolysaccharides (LPS) is increased in non-alcoholic fatty liver disease (NAFLD), but its relationship with liver inflammation is not defined. We studied Escherichia Coli-LPS in patients with biopsy-proven NAFLD, 25 simple steatosis (NAFL), and 25 non-alcoholic steatohepatitis (NASH), and in mice with diet-induced NASH. NASH patients had higher serum LPS and hepatocytes LPS localization than controls, which was correlated with serum zonulin and pNF-kappaB expression. Toll-like receptor 4 posi...
8 CitationsSource
#1Marcello MaidaH-Index: 17
#2Sandro SferrazzaH-Index: 1
Last. A. VitelloH-Index: 1
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ABSTRACT Background In Italy, the spread of the COVID-19 pandemic has stressed the entire healthcare system and required a huge re-organization of many Divisions, including those of Gastroenterology. Aims to assess the impact of COVID-19 pandemic on Gastroenterology Divisions across Italy. Methods All members of the Italian Society of Gastroenterology (SIGE) were invited to answer a web-based survey. Results Data of 121 hospitals from all 20 Italian regions were analyzed. Overall, 10.7% Gastroen...
2 CitationsSource
#1Lars Bossen (University of Milan)H-Index: 2
#2Paola Rebora (University of Milan)H-Index: 12
Last. Giancarlo Labbadia (Sapienza University of Rome)H-Index: 18
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INTRODUCTION: In primary biliary cholangitis (PBC) macrophages are involved in liver inflammation and fibrosis. The macrophage activation markers, soluble (s)CD163 and mannose receptor (sMR) are associated with liver disease severity and prognosis in other chronic liver diseases. We aimed to investigate sCD163 and sMR in PBC patients. METHODS: We investigated PBC patients from the Italian PBC Study Group cohort and measured macrophage activation markers in serum at study enrolment. Patients were...
#1Lindsey Kennedy (IU: Indiana University)H-Index: 7
#1Lindsey Kennedy (IU: Indiana University)H-Index: 12
Last. Domenico Alvaro (Sapienza University of Rome)H-Index: 58
view all 13 authors...
#1Guido Carpino (Sapienza University of Rome)H-Index: 38
#2L. Nevi (Sapienza University of Rome)H-Index: 5
Last. Eugenio Gaudio (Sapienza University of Rome)H-Index: 44
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BACKGROUND AND AIMS: Mechanisms underlying the repair of extrahepatic biliary tree (EHBT) after injury have been scarcely explored. The aims of this study were to evaluate, by using a lineage tracing approach, the contribution of peribiliary gland (PBG) niche in the regeneration of EHBT after damage and to evaluate, in vivo and in vitro, the signaling pathways involved. APPROACH AND RESULTS: Bile duct injury was induced by the administration of 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) die...
5 CitationsSource
#1Keisaku Sato (IU: Indiana University)H-Index: 5
#2Shannon Glaser (A&M: Texas A&M University)H-Index: 53
Last. Gianfranco Alpini (IU: Indiana University)H-Index: 67
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AbstractIntroductionCholangiocarcinoma (CCA) is a liver cancer derived from the biliary tree with a less than 30% five-year survival rate. Early diagnosis of CCA is challenging and treatment option...
#1N. CazzagonH-Index: 2
#1Nora CazzagonH-Index: 14
Last. Domenico AlvaroH-Index: 58
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#1A. GentiliniH-Index: 18
#2Giulia LoriH-Index: 3
Last. Fabio MarraH-Index: 66
view all 10 authors...