Recombinant human osteogenic protein 1 is a potent stimulator of the synthesis of cartilage proteoglycans and collagens by human articular chondrocytes

Objective . To study the effects of recombinant human osteogenic protein‐1 (rHuOP‐1; bone morphogenetic protein‐7) on proteoglycan and collagen synthesis by human articular chondrocytes. Methods . Articular chondrocytes from fetal, adolescent, and adult human donors were cultured in alginate beads for 4 days in a mixture of Ham's F‐12, Dulbecco's modified Eagle's medium, 10% fetal bovine serum (FBS), then for an additional 3‐10 days in the...