Platelet-Derived Growth Factor-BB Restores Human Immunodeficiency Virus Tat-Cocaine-Mediated Impairment of Neurogenesis: Role of TRPC1 Channels

Platelet-derived growth factor-BB (PDGF-BB) has been reported to provide tropic support for neurons in the CNS. However, whether PDGF-BB regulates neurogenesis, especially in the context of HIV-associated neurological disorder and drug abuse, remains essentially unknown. In this study, we demonstrate that pretreatment of rat hippocampal neuronal progenitor cells (NPCs) with PDGF-BB restored proliferation that had been impaired by HIV Tat–cocaine...