The Journal of Neuroscience
Papers 37085
1 page of 3,709 pages (37.1k results)
Many neurodegenerative and neurological diseases are rooted in dysfunction of the neuroimmune system, therefore, manipulating this system has strong therapeutic potential. Prior work has shown that exposing mice to flickering lights at 40Hz drives gamma frequency (∼40Hz) neural activity and recruits microglia, the primary immune cells of the brain, revealing a novel method to manipulate the neuroimmune system. However, the biochemical signaling mechanisms between 40Hz neural activity and immune ...
Multiple lines of evidence link economic choices to the orbitofrontal cortex (OFC), but other brain regions may contribute to the computation and comparison of economic values. A particularly strong candidate is the basolateral amygdala (BLA). Amygdala lesions impair performance in reinforcer devaluation tasks, suggesting that BLA contributes to value computation. Furthermore, previous studies of BLA found neuronal activity consistent with a value representation. Here we recorded from the BLA of...
Interfering with memory reconsolidation or inducing memory extinction are two approaches for weakening maladaptive memories in disorders such as addiction and post-traumatic stress disorder. Both extinction and reconsolidation are regulated by intracellular protein kinases and phosphatases, and interfering with these signaling molecules can alter memory strength. The calcium-dependent protein phosphatase, calcineurin (CaN), has been implicated in both the consolidation and extinction of fear mem...
An abundant literature has highlighted the importance of the nucleus accumbens core (NAcC) in behavioral tasks dependent on external stimuli. Yet, some studies have also reported the absence of involvement of the NAcC in stimuli processing. We aimed at comparing, in male rats, the underlying neuronal determinants of incentive and instructive stimuli in the same task. We developed a variant of a GO/NOGO task that reveals important differences in these two types of stimuli. The incentive stimulus ...
Categorization allows organisms to generalize existing knowledge to novel stimuli and to discriminate between physically similar yet conceptually different stimuli. Humans, nonhuman primates, and rodents can readily learn arbitrary categories defined by low-level visual features, and learning distorts perceptual sensitivity for category-defining features such that differences between physically similar yet categorically distinct exemplars are enhanced while differences between equally similar bu...
Intrinsic connectivity networks (ICNs) identified through task-free fMRI (tf-fMRI) offer the opportunity to investigate human brain circuits involved in language processes without requiring participants to perform challenging cognitive tasks. In this study, we assessed the ability of tf-fMRI to isolate reproducible networks critical for specific language functions and often damaged in primary progressive aphasia (PPA). First, we performed whole-brain seed-based correlation analyses on tf-fMRI da...
The ventral pallidum (VP) is a central node in the reward system strongly implicated in reward and addiction. While the majority of VP neurons is GABAergic and encodes reward, recent studies revealed a novel glutamatergic neuronal population in the VP (VPvGluT2), whose activation generates aversion. Withdrawal from drugs has been shown to induce drastic synaptic changes in neuronal populations associated with reward, such as the ventral tegmental area (VTA) or nucleus accumbens neurons, but less...
Zika virus (ZIKV) infection during pregnancy has been causally linked to a constellation of neurodevelopmental deformities in the fetus resulting in a disease termed Congenital Zika Syndrome (CZS). Here we detail how ZIKV infection produces extensive neuropathology in the developing mouse brain and spinal cord of both sexes. Surprisingly, neuropathology differs depending on viral strain with a French Polynesian isolate producing primarily excitotoxicity and a Brazilian isolate being almost exclu...
Cocaine-driven changes in the modulation of neurotransmission by neuromodulators are poorly understood. The ventral pallidum (VP) is a key structure in the reward system, in which GABA neurotransmission is regulated by opioid neuropeptides, including dynorphin. However, it is not known whether dynorphin acts differently on different cell types in the VP and whether its effects are altered by withdrawal from cocaine. Here, we trained wild-type, D1-Cre, A2A-Cre or vGluT2-Cre:Ai9 male and female mi...
Top fields of study
Stimulus (physiology)