The Journal of Neuroscience
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#1Madan Ghimire (Southern Illinois University School of Medicine)
#2Rui Cai (Southern Illinois University School of Medicine)H-Index: 10
Last. Donald M. Caspary (Southern Illinois University School of Medicine)H-Index: 49
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Presence of novel or degraded communication sounds likely results in activation of basal forebrain cholinergic neurons increasing release of acetylcholine (ACh) onto pre- and post-synaptic nicotinic acetylcholine receptors (nAChRs) in primary auditory cortex (A1). nAChR subtypes include high-affinity heteromeric nAChRs commonly composed of α4 and β2 subunits and low-affinity homomeric nAChRs composed of α7 subunits. In young male FBN rats, we detail: 1) the distribution/expression of nAChR subun...
#1Anna Cavaccini (IIT: Istituto Italiano di Tecnologia)H-Index: 4
#2Caitlin A. Durkee (UMN: University of Minnesota)H-Index: 2
Last. Alfonso Araque (UMN: University of Minnesota)H-Index: 39
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Despite extensive research into understanding synaptic mechanisms of striatal plasticity, the functional role played by astrocytes in this region remains to be fully elucidated. It was recently demonstrated that high-frequency stimulation (HFS) of cortical inputs induced long-term depression (LTD) mediated by adenosine A1 receptor (A1R) activation at corticostriatal synapses of the direct pathway (cortico-dSPN) in the dorsolateral striatum (DLS). Because astrocyte-derived adenosine has been show...
#1Andrea L. Courtney (Stanford University)H-Index: 1
#2Meghan L. Meyer (Dartmouth College)H-Index: 11
Social connection is critical to well-being, yet how the brain reflects our attachment to other people remains largely unknown. We combined univariate and multivariate brain imaging analyses to assess whether and how the brain organizes representations of others based on how connected they are to our own identity. During an fMRI scan, female and male human participants (N=43) completed a self- and other-reflection task for 16 targets: the self, five close others, five acquaintances, and five cel...
#1Pei-Yi Lin (Vandy: Vanderbilt University)
#2Natali L. Chanaday (Vandy: Vanderbilt University)H-Index: 4
Last. Ege T. Kavalali (Vandy: Vanderbilt University)H-Index: 52
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Spontaneous neurotransmitter release is a fundamental property of synapses in which neurotransmitter filled vesicles release their content independent of presynaptic action potentials. Despite their seemingly random nature, these spontaneous fusion events can be regulated by Ca2+ signaling pathways. Here, we probed the mechanisms that maintain Ca2+ sensitivity of spontaneous release events in synapses formed between hippocampal neurons cultured from rats of both sexes. In this setting, we examin...
#1Ankita Chodankar (NCBS: National Centre for Biological Sciences)
#2Madhumala K. Sadanandappa (Dartmouth College)
Last. Mani Ramaswami (NCBS: National Centre for Biological Sciences)H-Index: 38
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Several features of the adult nervous systems develop in a “critical period,” (CP) during which high levels of plasticity allow neural circuits to be tuned for optimal performance. Through an analysis of long-term olfactory habituation (LTH) in female Drosophila, we provide new insight into mechanisms by which CPs are regulated in vivo. LTH manifests as a persistently reduced behavioural response to an odorant encountered for four continuous days and occurs together with the growth of specific, ...
#1Alan Kania (University of Camerino)H-Index: 2
#2Agata Szlaga (Jagiellonian University)
Last. Andrew L. Gundlach (Florey Institute of Neuroscience and Mental Health)H-Index: 46
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Binge-eating disorder is the most common eating disorder. Various neuropeptides play important roles in the regulation of feeding behavior, including relaxin-3 (RLN3), which stimulates food intake in rats through the activation of the relaxin-family peptide-3 receptor (RXFP3). Here we demonstrate that a likely mechanism underlying the orexigenic action of RLN3 is RXFP3-mediated inhibition of oxytocin- and arginine-vasopressin-synthesizing paraventricular nucleus (PVN) magnocellular neurosecretor...
#1Li Zhang (CAS: Chinese Academy of Sciences)
#2Qiwen Wu (CAS: Chinese Academy of Sciences)
Last. Yifeng Zhang (CAS: Chinese Academy of Sciences)
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Altered sensory experience in early life often leads to altered response properties of the sensory neurons. This process is mostly thought to happen in the brain, not in the sensory organs. We show that in the mouse retina of both sexes, exposed to a motion-dominated visual environment from eye-opening, the ON-OFF direction selective ganglion cells (ooDSGCs) develop significantly stronger direction encoding ability for motion in all directions. This improvement occurs independent of the motion d...
#1Ana S. Báez-Cordero (UNAM: National Autonomous University of Mexico)
#2Ana K. Pimentel-Farfan (UNAM: National Autonomous University of Mexico)
Last. Pavel E. Rueda-Orozco (UNAM: National Autonomous University of Mexico)H-Index: 13
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The substantia nigra pars reticulata (SNr), where the basal ganglia direct and indirect pathways converge, contains among the highest expression of cannabinoid receptors type 1 (CB1r) in the brain. Hence, SNr is an ideal locus to study pathway interactions and cannabinergic modulations. The objective of this study was to characterize the effects of systemic injections of the CB1r agonist (CP55940) on the balanced activity of the direct/indirect pathways in the SNr and its associated behaviors. T...
#1Judy A. Prasad (U of C: University of Chicago)H-Index: 2
#2Briana J. Carroll (U of C: University of Chicago)
Last. S. Murray Sherman (U of C: University of Chicago)H-Index: 56
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The cerebral cortex, with all its computational power, can only influence behavior via corticofugal connections originating from layer 5 (L5) cells (Sherman & Guillery, 2013). To begin to establish the global pattern of these outputs, we examined L5 efferents originating from four cortical areas: somatosensory, visual, motor and prefrontal (i.e., ventromedial orbitofrontal) cortex. We injected Cre-dependent adeno-associated virus in an Rbp4-Cre transgenic mouse line (both sexes) to label these L...
Top fields of study
Stimulus (physiology)