Cytosolic Phospholipase A2 Modulates TLR2 Signaling in Synoviocytes
Abstract
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic synovitis leading to destruction of cartilage and bone. PLA2 enzymes are key players in inflammation regulating the release of unsaturated fatty acids such as arachidonic acid (AA), a precursor of pro-inflammatory eicosanoids. Several lines of evidence point to toll-like receptors (TLRs) as drivers of synovitis and joint destruction in RA. However, few studies have...
Paper Details
Title
Cytosolic Phospholipase A2 Modulates TLR2 Signaling in Synoviocytes
Published Date
Apr 20, 2015
Journal
Volume
10
Issue
4
Pages
e0119088 - e0119088
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