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Astrid Jullumstrø Feuerherm
Norwegian University of Science and Technology
17Publications
8H-index
195Citations
Publications 17
Newest
#1Astrid Jullumstrø Feuerherm (NTNU: Norwegian University of Science and Technology)H-Index: 8
#2Edward A. Dennis (UCSD: University of California, San Diego)H-Index: 80
Last.Bent Johansen (NTNU: Norwegian University of Science and Technology)H-Index: 22
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Background Cytosolic phospholipase A2 group IVA (cPLA2α)-deficient mice are resistant to collagen-induced arthritis, suggesting that cPLA2α is an important therapeutic target. Here, the anti-inflammatory effects of the AVX001 and AVX002 cPLA2α inhibitors were investigated.
Metastatic disease is the leading cause of death in breast cancer patients. Disrupting the cancer cell’s ability to migrate may be a strategy for hindering metastasis. Cytosolic phospholipase A2 α (cPLA2α), along with downstream proinflammatory and promigratory metabolites, has been implicated in several aspects of tumorigenesis, as well as metastasis, in various types of cancer. In this study, we aim to characterize the response to reduced cPLA2α activity in metastatic versus non-metastatic cel...
#1Eugene Kim (NTNU: Norwegian University of Science and Technology)H-Index: 10
#2Hanna Maja Tunset (NTNU: Norwegian University of Science and Technology)H-Index: 2
Last.Siver Andreas Moestue (NTNU: Norwegian University of Science and Technology)H-Index: 13
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Background Group IVA cytosolic phospholipase A2 (cPLA2α) plays an important role in tumorigenesis and angiogenesis. It is overexpressed in basal-like breast cancer (BLBC), which is aggressive and usually triple-negative, making it unresponsive to current targeted therapies. Here, we evaluated the anti-angiogenic effects of a specific cPLA2α inhibitor, AVX235, in a patient-derived triple-negative BLBC model.
#1Syed Majid Bukhari (CUI: COMSATS Institute of Information Technology)H-Index: 3
#2Astrid Jullumstrø Feuerherm (University of the Sciences)H-Index: 8
Last.Erik Fuglset (University of the Sciences)H-Index: 1
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The activation of PLA 2 by means of pro-inflammatory cytokines results in the subsequent release of arachidonic acid (AA) and generates eicosanoids, which further propagate inflammation. By 6the cyclooxygenases (COX1/2) responsible for the enzymatic conversion of AA to eicosanoids, the non-steroidal anti-inflammatory drugs are effective in relieving the pain and discomfort of inflammation. By using AA release assay as a guide for biological and anti-inflammatory activity, novel compound 1- O -(3...
#1Randi Magnus Sommerfelt (NTNU: Norwegian University of Science and Technology)H-Index: 3
#2Astrid Jullumstrø Feuerherm (NTNU: Norwegian University of Science and Technology)H-Index: 8
Last.Bent Johansen (NTNU: Norwegian University of Science and Technology)H-Index: 22
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Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic synovitis leading to destruction of cartilage and bone. PLA2 enzymes are key players in inflammation regulating the release of unsaturated fatty acids such as arachidonic acid (AA), a precursor of pro-inflammatory eicosanoids. Several lines of evidence point to toll-like receptors (TLRs) as drivers of synovitis and joint destruction in RA. However, few studies have addressed the implication of PLA2 activity downstream TL...
Group IVA cytosolic phospholipase A2 (GIVA cPLA2) is the rate-limiting provider of pro-inflammatory mediators in many tissues and is thus an attractive target for the development of novel anti-inflammatory agents. In this work, we present the synthesis of new thiazolyl ketones and the study of their activities in vitro, in cells, and in vivo. Within this series of compounds, methyl 2-(2-(4-octylphenoxy)acetyl)thiazole-4-carboxylate (GK470) was found to be the most potent inhibitor of GIVA cPLA2,...
#1Jamal Naderi (NTNU: Norwegian University of Science and Technology)
#2Astrid Jullumstrø Feuerherm (NTNU: Norwegian University of Science and Technology)H-Index: 8
Last.Bent Johansen (NTNU: Norwegian University of Science and Technology)H-Index: 22
view all 4 authors...
Diet macronutrient composition affects insulin action(1) . Insulin is essential for metabolic homeostasis in mammals(2) . THP-1 is a human myeloid leukemia cell line(3) which is a suitable model-system for mimicking human monocytes and macrophages in metabolic inflammation, diabetes and vasculature-related research(4-6) . In this study, we used THP-1 cells to investigate if insulin affect proliferation. Actively proliferating THP-1 cells were serum starved prior to treatment with varying doses o...
The plant Sclerochloa dura is traditionally used in South-East Serbia to treat menstrual disorders characterized by pain and excessive bleeding. According to statements of subjects, a reduction in bleeding and pain is expe- rienced shortly after oral intake. The focus of this investigation was to deter- mine the inhibitory effects of the plant on the arachidonic acid (AA) cascade along with the spectrophotometric determination of its antioxidant capacity. The AA release assay was performed using...
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