Original paper
The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification
Abstract
The precise relationship of embryonic stem cells (ESCs) to cells in the mouse embryo remains controversial. We present transcriptional and functional data to identify the embryonic counterpart of ESCs. Marker profiling shows that ESCs are distinct from early inner cell mass (ICM) and closely resemble pre-implantation epiblast. A characteristic feature of mouse ESCs is propagation without ERK signalling. Single-cell culture reveals that...
Paper Details
Title
The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification
Published Date
May 25, 2014
Journal
Volume
16
Issue
6
Pages
513 - 525
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Notes
History