Original paper
Mutation of POLB Causes Lupus in Mice
Abstract
A replication study of a previous genome-wide association study (GWAS) suggested that a SNP linked to the POLB gene is associated with systemic lupus erythematosus (SLE). This SNP is correlated with decreased expression of Pol β, a key enzyme in the base excision repair (BER) pathway. To determine whether decreased Pol β activity results in SLE, we constructed a mouse model of POLB that encodes an enzyme with slow DNA polymerase activity. We...
Paper Details
Title
Mutation of POLB Causes Lupus in Mice
Published Date
Jan 1, 2014
Journal
Volume
6
Issue
1
Pages
1 - 8
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Notes
History