Original paper
Serendipitous discovery of two highly selective inhibitors of bacterial luciferase
Abstract
Herein, we report the serendipitous discovery of two highly selective inhibitors of bacterial luciferase, N-phenacylthiazolium bromide (PTB) and pifithrin-α (PFT-α). These compounds, which are both derivatives of N-phenacylthiazolium salts, comprise a previously unreported class of luciferase inhibitors that are effective both in vitro and in live bacteria. Interestingly, although they are structurally similar, these compounds appear to elicit...
Paper Details
Title
Serendipitous discovery of two highly selective inhibitors of bacterial luciferase
Published Date
Sep 1, 2013
Journal
Volume
69
Issue
36
Pages
7692 - 7698
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Notes
History