Effects of BMY21190, an Inhibitor of cAMP Phosphodiesterase, on Infarct Size and Myeloperoxidase Activity in the Ischemic Myocardium of a Canine Occlusion-Reperf usion Model

This study was performed to assess the effect of BMY21190, an inhibitor of cAMP phosphodiesterase, on infarct size using a canine ischemic model that underwent a 90-min occlusion and a 6-hour reperfusion of the left coronary artery. The infarct zone/area at risk of the BMY21190 group was significantly smaller than that of the vehicle group (36.1 +/- 7.8%; 62.4 +/- 4.3%, respectively; p < 0.05). Myeloperoxidase activity, an indicator of...