Crystal structure of the capsular polysaccharide synthesizing protein CapE of Staphylococcus aureus
Abstract
Enzymes synthesizing the bacterial CP (capsular polysaccharide) are attractive antimicrobial targets. However, we lack critical information about the structure and mechanism of many of them. In an effort to reduce that gap, we have determined three different crystal structures of the enzyme CapE of the human pathogen Staphylococcus aureus. The structure reveals that CapE is a member of the SDR (short-chain dehydrogenase/reductase) super-family...
Paper Details
Title
Crystal structure of the capsular polysaccharide synthesizing protein CapE of Staphylococcus aureus
Published Date
Jun 1, 2013
Journal
Volume
33
Issue
3
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