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Hepatoprotective activity of Tribulus terrestris extract against acetaminophen-induced toxicity in a freshwater fish (Oreochromis mossambicus)

Published on Dec 1, 2011in In Vitro Cellular & Developmental Biology – Animal 1.65
· DOI :10.1007/s11626-011-9457-9
P. Kavitha4
Estimated H-index: 4
(BDU: Bharathidasan University),
R. Ramesh5
Estimated H-index: 5
(BDU: Bharathidasan University)
+ 2 AuthorsP. Subramanian7
Estimated H-index: 7
(BDU: Bharathidasan University)
The potential protective role of Tribulus terrestris in acetaminophen-induced hepatotoxicity in Oreochromis mossambicus was investigated. The effect of oral exposure of acetaminophen (500 mg/kg) in O. mossambicus at 24-h duration was evaluated. The plant extract (250 mg/kg) showed a remarkable hepatoprotective activity against acetaminophen-induced hepatotoxicity. It was judged from the tissue-damaging level and antioxidant levels in liver, gill, muscle and kidney tissues. Further acetaminophen impact induced a significant rise in the tissue-damaging level, and the antioxidant level was discernible from the enzyme activity modulations such as glutamate oxaloacetic transaminase, glutamate pyruvic transaminase, alkaline phosphatase, acid phosphatase, glucose-6-phosphate dehydrogenase, lactate dehydrogenase, superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione S-transferase, lipid peroxidase and reduced glutathione. The levels of all these enzymes have significantly (p < 0.05) increased in acetaminophen-treated fish tissues. The elevated levels of these enzymes were significantly controlled by the treatment of T. terrestris extract (250 kg/mg). Histopathological changes of liver, gill and muscle samples were compared with respective controls. The results of the present study specify the hepatoprotective and antioxidant properties of T. terrestris against acetaminophen-induced toxicity in freshwater fish, O. mossambicus.
  • References (54)
  • Citations (35)
Published on Jan 1, 2011in In Vitro Cellular & Developmental Biology – Animal 1.65
Guojun Yin8
Estimated H-index: 8
Liping Cao8
Estimated H-index: 8
+ 2 AuthorsMiki Nakao31
Estimated H-index: 31
(Kyushu University)
The present study aims to evaluate the hepatoprotective and antioxidant effects of Hibiscus sabdariffa extract on the carbon tetrachloride (CCl4)-induced hepatocyte damage in fish and provide evidence as to whether it can be potentially used as a medicine for liver diseases in aquaculture. H. sabdariffa extract (100, 200, and 400 μg/mL) was added to the carp primary hepatocyte culture before (pre-treatment), after (post-treatment), and both before and after (pre- and post-treatment) the incubati...
Published on Jan 1, 2009
Rakesh Pundir2
Estimated H-index: 2
Gyanendra Singh2
Estimated H-index: 2
+ 1 AuthorsShubhini A. Saraf14
Estimated H-index: 14
The present investigation was aimed at studying the herbal hepatoprotective formulations, which are used to treat acute and chronic hepatic disorders in the population of Lucknow, Uttar Pradesh. The commercial preparations and their components, and dosage thereof widely used as liver protectives were compiled. The study was initiated from primary data collection through the convenient sampling. It was found that 70 % of patients suffering form liver disorders belonging to the age group of 25 to ...
Published on Jan 1, 2008in Journal of Environmental Biology 0.56
Marc Estiarte34
Estimated H-index: 34
Josep Peñuelas99
Estimated H-index: 99
+ 10 AuthorsE. Kovacs Lang1
Estimated H-index: 1
Root-surface phosphatase activities were measured in natural and semi-natural shrublands across an European climatic gradient of temperature and rainfall including Wales (WL), Denmark (DK), Netherlands (NL), Hungary (HU), Italy (IT) and Spain (SP). In each site a warming experiment was conducted since 1999 or 2001 by means of passive night-time warming using reflective curtains that covered the vegetation at night. The treatments increased yearly average soil temperatures around 0.8 degrees C in...
Published on Sep 1, 2007in Food and Chemical Toxicology 3.77
Shashi K. Ramaiah23
Estimated H-index: 23
(A&M: Texas A&M University)
Abstract Assessing liver damage in basic toxicology research and in preclinical toxicity testing is usually evaluated by serum biochemical parameters prior to confirmation by histopathology. With the advent of newer methods such as genomics and proteomics, there is increased enthusiasm to generate “novel” predictive markers to detect liver pathology even before the alterations in clinical and histopathology parameters occur. However, serum biochemical parameters (clinical pathology) when employe...
Published on Apr 1, 2007in Journal of Ethnopharmacology 3.41
Feng-Lin Yen17
Estimated H-index: 17
(KMU: Kaohsiung Medical University),
Tzu Hui Wu7
Estimated H-index: 7
(KMU: Kaohsiung Medical University)
+ 1 AuthorsChun Ching Lin23
Estimated H-index: 23
(KMU: Kaohsiung Medical University)
Abstract Tu-Si-Zi, the seeds of Cuscuta chinensis Lam. (Convolvulaceae), is a traditional Chinese medicine that is commonly used to nourish and improve the liver and kidney conditions in China and other Asian countries. As oxidative stress promotes the development of acetaminophen (APAP)-induced hepatotoxicity, the aim of the present study was to evaluate and compare the hepatoprotective effect and antioxidant activities of the aqueous and ethanolic extracts of C chinensis on APAP-induced hepato...
Published on Mar 1, 2007in Applied Biochemistry and Biotechnology 2.14
Y. Z. Zheng1
Estimated H-index: 1
(CAS: Chinese Academy of Sciences),
W. S. Lan1
Estimated H-index: 1
(CAS: Chinese Academy of Sciences)
+ 2 AuthorsWilfred Chen59
Estimated H-index: 59
(UCR: University of California, Riverside)
A genetically engineered Escherichia coli cell expressing both organophosphorus hydrolase (OPH) and carboxyl esterase (CaE) B1 intracellularly was constructed and cultivated. The harvested wet cells were vacuum dried, and the storage stability of the dried cell powder was determined in terms of OPH activity. Over a period of 5 mo, the dried cells showed no significant decrease in the activities of the detoxifying enzymes. The crude enzymes in 50 mM citrate-phosphate buffer (pH 8.0) were able to ...
Ajay Kumar Gupta6
Estimated H-index: 6
Neelam Misra10
Estimated H-index: 10
Hepatoprotective activity of aqueous ethanolic extract of Chamomile recutita capitula against paracetamol induced hepatic damage in albino rats was observed. In the present study the effect of aqueous ethanolic extract of Chamomile recutita capitula on blood and liver glutathione, Na+ K+- ATPase activity, serum marker enzymes, serum bilirubin, glycogen and thiobarbutiric acid reactive substances against paracetamol induced damage in rats have been studied to find out the possible mechanism of he...
Published on Jul 1, 2005in Tropical Zoology 0.57
H. Bhattacharya2
Estimated H-index: 2
(Ocean University of China),
S.C. Zhang2
Estimated H-index: 2
(Ocean University of China),
Y. J. Wang1
Estimated H-index: 1
(Ocean University of China)
This study provides the first detailed table of normal development of the rosy barb embryo, from fertilization to post-hatching. We define six broad periods of embryogenesis, i.e. the zygote, cleavage, blastula, gastrula, segmentation and larval periods. These divisions highlight the changing spectrum of major developmental processes occurring during these periods. Stages that subdivide the periods are named, not numbered as in most other series. The stages and their names are based on morpholog...
Published on Jul 1, 2005in Brazilian Journal of Medical and Biological Research 1.85
John G. Scandalios44
Estimated H-index: 44
(NCSU: North Carolina State University)
Molecular oxygen (O2) is the premier biological electron acceptor that serves vital roles in fundamental cellular functions. However, with the beneficial properties of O2 comes the inadvertent formation of reactive oxygen species (ROS) such as superoxide (O2·-), hydrogen peroxide, and hydroxyl radical (OH·). If unabated, ROS pose a serious threat to or cause the death of aerobic cells. To minimize the damaging effects of ROS, aerobic organisms evolved non-enzymatic and enzymatic antioxidant defe...
K Samy Murugesh1
Estimated H-index: 1
V Channabasappa Yeligar1
Estimated H-index: 1
+ 1 AuthorsT Kumar Maity1
Estimated H-index: 1
The scientific evaluation of medicinal plants used in the preparation of folk remedies has provided modern medicine with effective pharmaceuticals for the treatment of diseases. The methanol extract of Berberis tinctoria Lesch (Berberidaceae) leaves was investigated for its hepatoprotective and antioxidant effects on paracetamol (750 mg/kg) induced acute liver damage in Wistar albino rats. Hepatoprotection activity was measured by using biochemical parameters such as serum glutamate oxalate tran...
Cited By35
Published on May 27, 2019in Environmental Science and Pollution Research 2.91
Valéria Giménez (University of Aveiro), Bruno Nunes20
Estimated H-index: 20
(University of Aveiro)
Over time, the consumption of pharmaceutical drugs has highly augmented, directly contributing for an increase of the discharges of these substances into sewage water due to excretion, and their direct release to the environment, with or without adequate treatment. Considering that part of the sewage water is dumped into rivers and seas, this is the major source of contamination of the aquatic environment. Paracetamol and acetylsalicylic acid are among the most worldwide consumed pharmaceutical ...
Published on Jun 1, 2019in Aquatic Toxicology 3.79
Sijia Liu1
Estimated H-index: 1
(JNU: Jinan University),
Sijia Liu (JNU: Jinan University)+ 0 AuthorsXiangping Nie12
Estimated H-index: 12
(JNU: Jinan University)
Abstract Paracetamol (APAP) is one of the most widely used anti-inflammatory and analgesic drugs in human being health care and has been universally detected in various aquatic environments. However, its potential adverse effects and toxic mechanisms on freshwater invertebrates still remain unclear. In the present study, the effects of APAP on the expressions of Nrf1 and the antioxidant related genes including GCLC , GST , GPX , CAT , TRX , TrxR and Prx1 in Daphnia magna ( D. magna ) were evalua...
Published on Apr 1, 2019in Aquaculture International 1.46
Jianmei Su (RMIT: RMIT University), Hongli Hou (HAU: Huazhong Agricultural University)+ 1 AuthorsYuliang Luo (HAU: Huazhong Agricultural University)
A 56-day feeding trial was conducted to evaluate the effects of replacing dietary soybean meal (SBM) with cottonseed meal (CSM) for juvenile common carp, Cyprinus carpio. Four isonitrogenous (34% crude protein) and isolipidic (6% crude lipid) diets were formulated by replacing 0%, 50%, 75%, and 100% of protein from SBM with protein from CSM (CSM0, CSM50, CSM75, CSM100, respectively). Each diet was assigned to triplicate tanks with 30 fish (initial body weight 4.23 ± 0.28 g) per tank, and fish we...
Published on Apr 1, 2019in Inflammopharmacology 3.84
Muhammad Daniyal2
Estimated H-index: 2
(Hunan University),
Muhammad Akram8
Estimated H-index: 8
(GCUF: Government College University, Faisalabad)
+ 5 AuthorsWang Wei92
Estimated H-index: 92
(Hunan University)
Background Herbal medicine plays an important role in health, particularly in remote parts of developing areas with few health facilities. According to WHO estimates, about three-quarters of the world's population currently use herbs or traditional medicines to treat various ailments, including liver diseases. Several studies have found that the use of medicinal plants was effective in the treatment of infectious and non-infectious diseases. Hepatitis and liver cirrhosis associated with many cli...
Published on Feb 1, 2019in Science of The Total Environment 5.59
Chengliang Sun2
Estimated H-index: 2
(UCR: University of California, Riverside),
Stacia Dudley3
Estimated H-index: 3
(UCR: University of California, Riverside)
+ 2 AuthorsJay Gan37
Estimated H-index: 37
(UCR: University of California, Riverside)
Abstract Many pharmaceutical and personal care products (PPCPs) enter agroecosystems during reuse of treated wastewater and biosolids, presenting potential impacts on plant development. Here, acetaminophen, one of the most-used pharmaceuticals, was used to explore roles of glutathione (GSH) conjugation in its biotransformation in crop plants. Acetaminophen was taken up by plants, and conjugated quickly with GSH. After exposure to 5 mg L −1 acetaminophen for 144 h, GSH-acetaminophen conjugates we...
Published on Feb 1, 2019in Environmental Science and Pollution Research 2.91
David Daniel1
Estimated H-index: 1
(University of Aveiro),
Ricardo Dionísio1
Estimated H-index: 1
(University of Aveiro)
+ 1 AuthorsBruno Nunes20
Estimated H-index: 20
(University of Aveiro)
The modern usage of pharmaceutical drugs has led to a progressive increase in their presence and environment concentrations, particularly in the aquatic compartment which is the most common final dumping location for this specific class of chemicals. These substances, due to their chemical and biological properties, can exert mostly uncharacterized toxic effects to non-target aquatic species, given the diverse pathways they activate, and the large number of putative targets in the wild. Among dr...
Published on Nov 1, 2018in Aquatic Toxicology 3.79
Jun Chul Park7
Estimated H-index: 7
(SKKU: Sungkyunkwan University),
Deok-Seo Yoon2
Estimated H-index: 2
(SKKU: Sungkyunkwan University)
+ 4 AuthorsJehee Lee49
Estimated H-index: 49
(SKKU: Sungkyunkwan University)
Abstract To investigate the adverse effect of two widely used pharmaceuticals, paracetamol (acetaminophen [APAP]) and oxytetracycline (OTC) on the marine rotifer Brachionus rotundiformis ( B. rotundiformis ), the animals were exposed to various environmentally-relevant concentrations. Up to date, acetaminophen and oxytetracycline have been considered as toxic, if used above threshold concentration, i.e. overdosed. However, this study demonstrated these two pharmaceuticals even at low concentrati...