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In Vitro Cellular & Developmental Biology – Animal
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Xin-Yu Gong (China-Japan Friendship Hospital), Yun Zhang (China-Japan Friendship Hospital)
MicroRNAs (miRNAs) are recognized to hold essential parts in the course of pathophysiology participating in myocardial ischemia/reperfusion (I/R) injury. The current study was intended to appraise the functional implication and underlying regulatory mechanism action of miR-20a in myocardial I/R injury. In cardiomyocyte hypoxia/reoxygenation (H/R) model simulating I/R, we observed that miR-20a was diminished in H9c2 cells subjected to H/R. The miR-20a mimics promoted cardiomyocyte viability and r...
Wenshuai Tang (CQMU: Chongqing Medical University), Deqing Lin (CQMU: Chongqing Medical University)+ -3 AuthorsFuping Li (CQMU: Chongqing Medical University)
Autophagy plays a critical role in cardiac hypoxia/reoxygenation (H/R). Studies indicated that the phosphatase and tensin homolog (PTEN) influences level of autophagy. This study aims to explore the role of PTEN mediating a specific autophagy, mitophagy, in cardiac H/R injury. H9c2 cells were cultured and suffered hypoxia and reoxygenation treatment. To inhibit function of PTEN protein, bpv (phen) was added into medium throughout the process of H/R injury. In addition, we overexpressed the apuri...
Zhaojin Luan (Inner Mongolia Agricultural University), Xiaomei Fan2
Estimated H-index: 2
(Inner Mongolia Medical University)
+ -3 AuthorsJiaxin Zhang2
Estimated H-index: 2
(Inner Mongolia Agricultural University)
Androgens are involved in maintaining epididymal structure and function. In the present study, primary culture of goat EECs and effect of testosterone on expression of glutathione peroxidase-5 (GPX5) in goat epididymal epithelial cells (EECs) were investigated. The EECs isolated from 12-mo-old goat caput epididymis were cultured with testosterone in vitro, and expression of glutathione peroxidase-5 (GPX5) and androgen receptors (ARs) was analyzed. Our results showed that testosterone effectively...
Xuefeng Tan7
Estimated H-index: 7
(Nantong University),
Linqing Zou5
Estimated H-index: 5
(Nantong University)
+ -3 AuthorsHaoming Li2
Estimated H-index: 2
(Nantong University)
Docosahexaenoic acid (DHA) is the most abundant n-3 polyunsaturated fatty acid in the human brain and works as an anticancer agent to induce cell cycle arrest and apoptosis in glioblastoma multiforme (GBM) cell lines. However, little is known about the connection between DHA and autophagy in GBM cells. We found that high-dose DHA caused cellular autophagy in cultured U251 and U118 GBM cell lines, but there was no effect with a low dose. Moreover, after treatment with a high dose of DHA at 12, 24...
Gamze Tan5
Estimated H-index: 5
(Aksaray University)
Vascular endothelial growth factor (VEGF) inhibition forms the basis for anti-angiogenic therapies. With the methods based on the monoclonal antibody-mediated typical VEGF blockade, pathological angiogenesis in the tumor microenvironment is inhibited and the limitation of tumor growth is provided; however, the existing tumor tissue cannot be intervened. In this study, the anti-angiogenic effects of Semaphorin (SEMA) 3F, which has frequently been reported to have tumor suppressive properties, on ...
Tamra Reall1
Estimated H-index: 1
(ARS: Agricultural Research Service),
Susanne Kraus (Bayer)+ -3 AuthorsDavid Stanley31
Estimated H-index: 31
(ARS: Agricultural Research Service)
The fall armyworm, Spodoptera frugiperda (Sf), is a polyphagous lepidopteran herbivore that consumes more than 80 plant species, including many economically important crops, such as corn, soybeans, and sorghum. While already a serious pest in the Americas, it was recently introduced into Africa, India, and China. Because of its high economic costs in the New World and the continent-wide damage potentials in Africa, research to develop advanced pest management technologies is necessary. We are su...
Meng Wang (SDU: Shandong University), Zengtao Wang (SDU: Shandong University)+ -3 AuthorsZhibo Liu (SDU: Shandong University)
Osteosarcoma is prevalent worldwide and characterized as a challenging health burden. It has been increasingly indicated that long non-coding RNAs (lncRNAs) are significant in pathological processes of numerous cancers, exerting oncogenic or tumor-suppressive function. However, the participation of KCNQ1OT1 in osteosarcoma has not been elaborated. In this study, we focus on interrogating the function of KCNQ1OT1 and its underlying mechanism in osteosarcoma. Our work demonstrated the upregulation...
Hao Zhang11
Estimated H-index: 11
,
Fang Chen + -3 AuthorsJinsong Pi1
Estimated H-index: 1
Intestinal epithelial cells (IECs) not only have an absorption function but also act as a physical barrier between the body and the intestinal bacterial flora. Damage to IECs leads to the breakdown of this barrier and has negative effects on animal health. Intestinal epithelial damage is frequently associated with long-term acute stress, such as increased temperature and new stress management models. The intestinal epithelial damage caused by environmental stress has been linked to oxidative str...
Guorui Zhang1
Estimated H-index: 1
(SJTU: Shanghai Jiao Tong University),
Xiao-Ming Li4
Estimated H-index: 4
(SJTU: Shanghai Jiao Tong University)
+ -3 AuthorsXuejun Guo9
Estimated H-index: 9
(SJTU: Shanghai Jiao Tong University)
The immunosuppressive function of mesenchymal stem cells (MSCs) is well known. Aryl hydrocarbon receptor (AhR), a transcription factor of the bHLH/PAS family, is widely expressed in several cells and is involved in various physiological and pathological processes. Previously, we found that the expression of AhR was downregulated in MSCs isolated from mice with neutrophilic asthma and that the activation of AhR enhanced the function of MSCs to alleviate neutrophilic asthma. We hypothesized that A...
Published on Jun 25, 2019in In Vitro Cellular & Developmental Biology – Animal 1.65
Fuben Xu4
Estimated H-index: 4
(Guangxi Medical University),
Huayu Wu7
Estimated H-index: 7
(Guangxi Medical University)
+ 3 AuthorsJinmin Zhao21
Estimated H-index: 21
(Guangxi Medical University)
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