Modulation of Angiotensin II–Mediated Cardiac Remodeling by the MEF2A Target Gene Xirp2

The vasoactive peptide angiotensin II (Ang II) is a potent cardiotoxic hormone whose actions have been well studied, yet questions remain pertaining to the downstream factors that mediate its effects in cardiomyocytes.The in vivo role of the myocyte enhancer factor (MEF)2A target gene Xirp2 in Ang II-mediated cardiac remodeling was investigated.Here we demonstrate that the MEF2A target gene Xirp2 (also known as cardiomyopathy associated gene 3...