Effective gene therapy of congenital erythropoietic porphyria mice improved by a survival advantage of corrected cells
Volume: 40, Issue: 2, Pages: 277 - 277
Published: Mar 1, 2008
Abstract
The mechanism of excessive iron storage in patients with hereditary hemochromatosis caused by mutations of the HFE gene seems to be a failure to up-regulate hepcidin in the face of increased body iron. Since the cytokines IL-1 and IL-6 stimulate hepcidin transcription in the absence of HFE, chronic inflammatory states might counteract the effect of HFE mutations. We measured the pre-phlebotomy plasma levels of C reactive protein (CRP) and of...
Paper Details
Title
Effective gene therapy of congenital erythropoietic porphyria mice improved by a survival advantage of corrected cells
Published Date
Mar 1, 2008
Volume
40
Issue
2
Pages
277 - 277
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