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Sleep-disordered breathing: a new risk factor of suspected fatty liver disease in overweight children and adolescents?

Published on May 1, 2009in Sleep and Breathing2.326
· DOI :10.1007/s11325-008-0231-5
Stijn Verhulst25
Estimated H-index: 25
(University of Antwerp),
Sarah Jacobs3
Estimated H-index: 3
(University of Antwerp)
+ 6 AuthorsKristine Desager29
Estimated H-index: 29
(University of Antwerp)
Abstract
Introduction The aim of this retrospective study was to investigate if sleep-disordered breathing (SDB) was an independent predictor of suspected fatty liver disease in a clinical sample of overweight children and adolescents.
  • References (22)
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References22
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#1Leila Kheirandish-Gozal (University of Louisville)H-Index: 22
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#1Stijn VerhulstH-Index: 25
#2Koen Van HoeckH-Index: 1
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Objective: The aim of this study was to determine whether the severity of sleep-disordered breathing (SDB) was associated with increased levels of uric acid (UA), both in serum and in urine, as a marker of tissue hypoxia, in a sample of overweight and obese subjects, irrespective of indexes of adiposity. Methods: Consecutive subjects underwent polysomnography, fasting blood sampling, and 24-h urine collection. Outcome parameters were serum UA, UA excretion ([24-h urinary UA × serum creatinine]/u...
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#1Stijn VerhulstH-Index: 25
#2N. SchrauwenH-Index: 8
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#1Riva Tauman (University of Louisville)H-Index: 22
#2Louise O'Brien (University of Louisville)H-Index: 44
Last. David Gozal (University of Louisville)H-Index: 91
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C-reactive protein (CRP) and interleukin-6 (IL-6) are pro-inflammatory proteins and important risk factors for atherosclerosis. Plasma CRP levels in snoring children may or may not be elevated. Since obesity is prevalent among snoring children and is associated with elevated CRP levels, we aimed to investigate the relative contributions of sleep-disordered breathing (SDB) and obesity to the inflammatory processes in snoring children in this prospective study. Two hundred forty-four children (mea...
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#1Stijn Verhulst (University of Antwerp)H-Index: 25
#2N. SchrauwenH-Index: 8
Last. Kristine DesagerH-Index: 29
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Aims: To determine the prevalence of sleep-disordered breathing (SDB) in a clinical sample of overweight and obese children and adolescents, and to examine the contribution of fat distribution. Methods: Consecutive subjects without chronic lung disease, neuromuscular disease, laryngomalacia, or any genetic or craniofacial syndrome were recruited. All underwent measurements of neck and waist circumference, waist-to-hip ratio, % fat mass and polysomnography. Obstructive apnoea index ⩾1 or obstruct...
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#2N. SchrauwenH-Index: 8
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Aim: Only a limited number of studies, designed to establish normal values for sleep-related respiratory variables in children, have been reported, and all are non-European. The aim of this study was to expand the knowledge on normative data in children. Methods: Subjects ranging from 6 to 16 years were recruited and underwent full polysomnography. Only subjects without sleep disordered breathing or other sleep problems as assessed by clinical history were included. Results: Sixty subjects were ...
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Objective In adults, obstructive sleep apnea (OSA) is associated with insulin resistance and dyslipidemia. We aimed to establish correlation between OSA, serum lipid profile, and insulin levels in obese snoring children. Methods Consecutive obese children with habitual snoring were recruited. They underwent physical examination, overnight polysomnography (PSG), and metabolic studies. OSA was diagnosed if apnea hypopnea index (AHI) > 1.0, and cases were considered to have moderate to severe OSA i...
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ABSTRACT Although population prevalence is very difficult to establish, nonalcoholic fatty liver disease (NAFLD) is probably the most common cause of liver disease in the preadolescent and adolescent age groups. There seems to be an increase in the prevalence of NAFLD, likely related to the dramatic rise in the incidence of obesity during the past 3 decades. Despite an increase in public awareness, overweight/obesity and related conditions, such as NAFLD, remain underdiagnosed by health care pro...
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Background: Concern is growing about nonalcoholic fatty liver disease, not only because it is a common liver disorder but also because it is one of the leading causes of chronic liver disease. Unexplained elevations in aminotransferase concentrations have been strongly associated with adiposity and thus may represent nonalcoholic fatty liver disease. Objective: We investigated the relation between nonviral or nonalcoholic elevations in alanine aminotransferase (ALT) and the metabolic syndrome in...
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Background: There is growing evidence that non-alcoholic fatty liver disease (NAFLD) is a disease affecting not only the liver but also extrahepatic organs. Aim: To investigate whether in youths NAFLD is associated with extrahepatic complications such as subclinical atherosclerosis, cardiac abnormalities, hypertension, type 2 diabetes, decreased bone mineral density, renal dysfunction, obstructive sleep apnea, and polycystic ovary syndrome. Methods: We systematically reviewed PubMed; Scopus; Emb...
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#1Slava Berger (Johns Hopkins University)H-Index: 5
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Obesity-related sleep breathing disorders such as obstructive sleep apnea (OSA) and obesity hypoventilation syndrome (OHS) cause intermittent hypoxia (IH) during sleep, a powerful trigger of oxidative stress. Obesity also leads to dramatic increases in circulating levels of leptin, a hormone produced in adipose tissue. Leptin acts in the hypothalamus to suppress food intake and increase metabolic rate. However, obese individuals are resistant to metabolic effects of leptin. Leptin also activates...
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Abstract Background/propose Sleep disturbance and excessive daytime sleepiness (EDS) have been reported in patients with hepatic cirrhosis with no hepatic encephalopathy (HE). The objective of this study was to evaluate daytime sleepiness and risk of obstructive sleep apnea (OSA) among liver cirrhosis patients. Material and methods A cross-sectional study was conducted at King Abdulaziz Medical City (KAMC)-Riyadh over a period of six months, using a structured questionnaire that investigated: 1)...
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Abstract Objective Obstructive sleep apnea (OSA) is common among overweight and obese children, and it is an independent risk factor for developing metabolic syndrome. However, the mechanisms linking OSA and metabolic syndrome are still unclear, but a role for adipose tissue dysfunction caused by intermittent hypoxia has been suggested. Therefore, the goal of this study was to investigate the relationship between OSA and systemic adipokine concentrations in overweight and obese children. Methods...
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#1Hui-Leng TanH-Index: 11
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Since the modern description of obstructive sleep apnea (OSA) in the mid-1970s, this disease has rapidly emerged as a highly prevalent condition in children. Its major importance derives from the vast array of end-organ morbidities associated with pediatric OSA, as knowledge and understanding on such adverse consequences and their pathophysiological mechanisms have accrued over the last several decades. In parallel, a remarkable transition is currently underway to radically change the diagnostic...
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Purpose Obstructive sleep apnea (OSA) is closely related to nonalcoholic fatty liver disease (NAFLD), though the mechanism is not conclusive as obesity is a confounder. The objective of this observational study was to investigate the correlation between these disorders in nonobese subjects.
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Abstract Obesity is considered a chronic subinflammatory disease and is a risk factor for many diseases such as sleep-disordered breathing (SDB). Although the interaction between obesity and sleep has been explored, not much is known about SDB in the adolescent population. Thus, the aims of this study were, first, to verify the effect of 1 year of interdisciplinary therapy on inflammatory markers in SDB and without SDB and, second, to investigate the influence of SDB on the result of the therapy...
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Obesity is a major risk factor for cardio-metabolic events. Obesity is linked to adipocyte dysfunction of which hypoxia is one of the main effectors. The adipocyte dysfunc- tion causes local inflammation and fibrosis but also promote systemic inflammation and ectopic fat depots themselves implicated in the pathophysiology of cardiometabolic comor- bidities associated with obesity. The "central" or "android" distribution of the adipose tissue, usually corresponding to an increase in visceral adip...