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Influence of virgin coconut oil on blood coagulation factors, lipid levels and LDL oxidation in cholesterol fed Sprague–Dawley rats

Published on Feb 1, 2008in E-spen, The European E-journal of Clinical Nutrition and Metabolism
· DOI :10.1016/j.eclnm.2007.09.003
K.G. Nevin1
Estimated H-index: 1
(UoK: University of Kerala),
T. Rajamohan1
Estimated H-index: 1
(UoK: University of Kerala)
Cite
Abstract
Summary Background aims Experimental and epidemiological studies indicate an association between dietary saturated fatty acids and thrombosis, but the effects of individual fatty acids on haemostasis are still controversial. The purpose of this research is to evaluate the effect of feeding virgin coconut oil (VCO) on blood coagulation factors, lipid levels and in vitro oxidation of LDL in comparison with copra oil (CO) and sunflower oil (SFO) in cholesterol (1%) and oil (10% w/w) fed rats. Methods Rats were given the test oils along with cholesterol for 45 days. After the experimental period, serum cholesterol and triglyceride levels, thrombotic risk factor levels viz . fibrin, fibrinogen, factor V, 6-ketoPGF1α and prothrombin time were measured. In vitro Cu 2+ induced oxidation of LDL, erythrocyte membrane and LDL TBARS content and plasma antioxidant vitamins (A and E) were also evaluated. Results Administration of VCO showed significant antithrombotic effect compared to copra oil and the effects were comparable with sunflower oil fed animals. The antioxidant vitamin levels were found to be higher in VCO fed animals than other groups. LDL isolated from VCO fed animals when subjected to oxidant (Cu 2+ ) in vitro showed significant resistance to oxidation as compared to the LDL isolated from other two groups. Dietary administration of VCO reduced the cholesterol and triglyceride levels and maintained the levels of blood coagulation factors. Results also indicate that VCO feeding can prevent the oxidation of LDL from oxidants. These properties of VCO may be attributed to the presence of biologically active unsaponifiable components viz . vitamin E, provitamin A, polyphenols and phytosterols.
  • References (64)
  • Citations (58)
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References64
Newest
Published on Apr 27, 2009in Nutrition Reviews5.78
Manfred Steiner1
Estimated H-index: 1
Vitamin E has emerged as a major factor in the prevention and inhibition of cardiovascular disease. The inhibition of platelet function, especially adhesion, which is an important event in the development and propagation of cardiovascular disease, plays a crucial role in the beneficial effect that vitamin E exerts on such diseases. Although it is best known for its antioxidant activity, vitamin E interferes with platelet adhesion via a mechanism that is independent of this action. Vitamin E-indu...
Published on Jan 1, 2005in Thrombosis Research3.27
Xinkang Wang13
Estimated H-index: 13
(BMS: Bristol-Myers Squibb),
Lin Xu1
Estimated H-index: 1
(BMS: Bristol-Myers Squibb)
Abstract Introduction/Objectives Animal models are important tools in thrombosis research and preclinical drug development. Ferric chloride has been widely used to induce arterial thrombosis in a variety of species. However, almost all previous reports applied a very high concentration of ferric chloride (10–60%) to induce thrombus formation leading to difficulties in evaluating the efficacy of antithrombotic agents. Thus, the purpose of this study was to refine the ferric-chloride-induced throm...
Published on Nov 1, 2004in Clinical Biochemistry2.43
Emre Sarandol20
Estimated H-index: 20
(Uludağ University),
Özlem aŞafak1
Estimated H-index: 1
(Uludağ University)
+ 1 AuthorsGürkan Uncu13
Estimated H-index: 13
(Uludağ University)
Abstract Objectives. Lipoprotein oxidation has been implicated in the pathogenesis of preeclampsia and paraoxonase, an antioxidant enzyme shown to protect lipoproteins from being oxidized. The aim of the present study was to evaluate oxidizability of apolipoprotein B-containing lipoproteins and serum paraoxonase/arylesterase activities in preeclampsia. Design and methods. Twenty-one women with mild preeclampsia, 21 women with severe preeclampsia, and 20 women with normal uncomplicated pregnancy ...
Published on Sep 1, 2004in Clinical Biochemistry2.43
Kottayath Govindan Nevin3
Estimated H-index: 3
(UoK: University of Kerala),
Thankappan Rajamohan10
Estimated H-index: 10
(UoK: University of Kerala)
Objectives: The present study was conducted to investigate the effect of consumption of virgin coconut oil (VCO) on various lipid parameters in comparison with copra oil (CO). In addition, the preventive effect of polyphenol fraction (PF) from test oils on copper induced oxidation of LDL and carbonyl formation was also studied. Design and methods: After 45 days of oil feeding to Sprague–Dawley rats, several lipid parameters and lipoprotein levels were determined. PF was isolated from the oils an...
Published on May 1, 2004
Paul Nestel1
Estimated H-index: 1
Abstract Isoflavones, plant polyphenols with estrogenic activity, are becoming widely distributed in foods and sold as supplements. Their similarity to estrogens suggests potential cardiovascular benefits. Two major areas, those of lipid lowering and of improved vascular function, will be reviewed. The novel properties of isoflavone metabolites formed in vivo that may confer specific cardiovascular protection are documented. Although lipid lowering is at best modest, effects on vasculature have ...
Published on Mar 1, 2004in Recenti progressi in medicina
Patrizia Ferroni32
Estimated H-index: 32
,
Stefania Basili42
Estimated H-index: 42
(Sapienza University of Rome),
Giovanni Davì47
Estimated H-index: 47
Hypercholesterolemia and overt atherosclerotic disorders have been associated with a low-grade inflammation that involves not only the intrinsic cells of the artery wall, but also circulating cells. Platelets as well as monocytes participate importantly in this disease process through the release of a wide variety of biologically active substances. Recent findings on the inflammatory actions of platelets have opened new perspectives in the comprehension of the pathogenetic mechanism(s) of athero...
Published on Jan 1, 2004in Pharmaceutical Biology2.49
H. Sini1
Estimated H-index: 1
(UoK: University of Kerala),
K.S. Devi1
Estimated H-index: 1
(UoK: University of Kerala)
A chloroform extract from the anticancer herb Solanum trilobatum (CST) (Nadkarni, 1979) was analyzed and compared with reference antioxidants for its in vitro antioxidative properties such as scavenging of α,α-diphenyl-β-picryl hydrazyl (DPPH) and superoxide radicals, protection to deoxyribose degradation, reducing power, as well as inhibition of lipid peroxidation. Preliminary phytochemical analysis of CST by silica gel thin-layer chromatography showed the presence of simple phenols, phenolic a...
Published on Jan 1, 2004in Journal of Physiology and Pharmacology2.54
Dorota Cylwik3
Estimated H-index: 3
,
Andrzej Mogielnicki14
Estimated H-index: 14
+ 2 AuthorsBuczko W11
Estimated H-index: 11
The aim of the study was to evaluate the effect of L-arginine (L-Arg) on haemostasis in stasis model of venous thrombosis in renal hypertensive rats. The effect of the single dose (i.v.300 mg/kg bolus+300 mg/kg/h) and of the 10-day application (p.o. 1 g/kg, once daily) of L-Arg was determined. L-Arg reduced the blood pressure both in the acute and long-term application. The single dose of L-Arg decreased the occurrence rate of the thrombus whereas long-term administration reduced significantly t...
Published on Jun 6, 2003in Journal of Biological Chemistry
Yoshichika Kawai32
Estimated H-index: 32
,
Akiko Saito1
Estimated H-index: 1
+ 4 AuthorsKoji Uchida68
Estimated H-index: 68
Abstract It has been proposed that plasma low density lipoproteins (LDL) undergo oxidative modification before they can produce foam cells in atherosclerosis. The oxidation of LDL generates a variety of reactive aldehydic products, which covalently bind to the LDL apolipoprotein B-100 (apoB). In the present study, to investigate the mechanisms contributing to the modification of LDL, we analyzed oxidized cholesteryl esters generated during the autoxidation of LDL and characterized their covalent...
Cited By58
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Published on Apr 22, 2019
Renan da Silva Lima (UFSC: Universidade Federal de Santa Catarina), Jane Mara Block11
Estimated H-index: 11
(UFSC: Universidade Federal de Santa Catarina)
Published on Jan 1, 2019in Journal of Nutritional Biochemistry4.49
Marina Campos Zicker2
Estimated H-index: 2
(UFMG: Universidade Federal de Minas Gerais),
Ana Letícia Malheiros Silveira3
Estimated H-index: 3
(UFMG: Universidade Federal de Minas Gerais)
+ 7 AuthorsAdaliene Versiani Matos Ferreira12
Estimated H-index: 12
(UFMG: Universidade Federal de Minas Gerais)
Abstract The global rise in obesity rates is alarming since this condition is associated with chronic low-grade inflammation and secondary comorbidities as glucose intolerance, cardiovascular disease and liver damage. Therefore, a lot of dietary approaches are proposed to prevent and to treat obesity and its associated disorders. Virgin coconut oil (VCO) is well known as a functional food due to its significant amounts of medium-chain triglycerides. This study aimed to evaluate the effect of VCO...
Published on Oct 1, 2018in Trends in Food Science and Technology8.52
Arunaksharan Narayanankutty6
Estimated H-index: 6
(University of Calicut),
Soorya Parathodi Illam4
Estimated H-index: 4
(University of Calicut),
Achuthan C. Raghavamenon5
Estimated H-index: 5
(University of Calicut)
Abstract Background Edible oils, preferably plant origin are rich sources of fatty acids and other lipophilic antioxidants to the body. Among these, oils derived from the coconut kernel ( Cocos nucifera ) are widely used in India and the Asia Pacific, which includes copra oil (CO), virgin coconut oil (VCO) and refined, bleached and deodorized (RBD) oil. Based on the mode of preparation, their composition and biological effects vary. Scope and approach This review compares the physicochemical and...
Published on Aug 1, 2018in Journal of Food Science2.08
Umesh Patil1
Estimated H-index: 1
(PSU: Prince of Songkla University),
Soottawat Benjakul67
Estimated H-index: 67
(PSU: Prince of Songkla University)
Coconut palm (Cocos nuciferaL.) is an economic plant cultivated in tropical countries, mainly in the Asian region. Coconut fruit generally consists of 51.7% kernel, 9.8% water, and 38.5% shell. Coconut milk is commonly manufactured from grated coconut meat (kernel). Basically, coconut milk is an oil‐in‐water emulsion, stabilized by some proteins existing in the aqueous phase. Maximization of protein functionality as an emulsifier can enhance the coconut milk stability. In addition, some stabiliz...
Published on Aug 1, 2018in Food and Chemical Toxicology3.77
Fatemeh Mirzaei1
Estimated H-index: 1
(Kermanshah University of Medical Sciences),
Mozafar Khazaei12
Estimated H-index: 12
(Kermanshah University of Medical Sciences)
+ 2 AuthorsCyrus Jalili8
Estimated H-index: 8
(Kermanshah University of Medical Sciences)
Abstract Both dyslipidemia and Alzheimer disease (AD) are associated with aging. In this study, the effects of virgin coconut oil (VCO) on inflammasome and oxidative stress in Alzheimer's model (receiving Amyloid-β (Aβ)) and high-fat diet (HFD) model were determined. A total of 120 male Wistar rats, were divided into 12 groups (n = 10), including; healthy control, sham surgery, sham surgery receiving normal saline, HFD, HFD + 8% VCO, HFD + 10% VCO, Aβ received rats, Aβ + 8%VCO, Aβ + 10%VCO, HFD ...
Published on May 4, 2018in Journal of Dietary Supplements
Ademola C. Famurewa3
Estimated H-index: 3
,
Chima A. Ekeleme-Egedigwe2
Estimated H-index: 2
+ 3 AuthorsGoodness C. Ezechukwu1
Estimated H-index: 1
ABSTRACTResearch findings that suggest beneficial health effects of dietary supplementation with virgin coconut oil (VCO) are limited in the published literature. This study investigated the in vivo effects of a 5-week VCO-supplemented diet on lipid profile, hepatic antioxidant status, hepatorenal function, and cardiovascular risk indices in normal rats. Rats were randomly divided into 3 groups: 1 control and 2 treatment groups (10% and 15% VCO-supplemented diets) for 5 weeks. Serum and homogena...
Published on Jan 1, 2018in Trends in Food Science and Technology8.52
Kumar Ganesan4
Estimated H-index: 4
(Hong Kong Baptist University),
Kumeshini Sukalingam3
Estimated H-index: 3
(Hong Kong Baptist University),
Baojun Xu29
Estimated H-index: 29
(Hong Kong Baptist University)
Abstract Background Cardiovascular disease (CVD) is the number one leading disease which causes morbidity and mortality worldwide. The improper consumption of dietary vegetable oils is highly linked to the pathogenesis of CVD. The practice of using repeatedly heated oil is common among the populations due to its cost-effectiveness. Consumption of these oils generates free radicals that may cause potentially harmful and detrimental effect on CVS through the accumulation of total cholesterol (TC),...
Published on Oct 1, 2017in Tissue & Cell1.55
K.O. Ajeigbe6
Estimated H-index: 6
(Igbinedion University,Okada),
W.M. Owonikoko (Igbinedion University,Okada)+ 2 AuthorsG. Adeleye (Ekiti State University)
Abstract In this biphasic study, 45 male wistar rats were divided into 9 groups. In Phase 1, Group 1 was treated with normal saline and served as the overall control, group 2 was treated with 95% Ethanol and represents the ulcer control, groups 3 and 4 received coconut water (CW; 4 ml/100 g BWt) and milk (CM; 4 ml/100 g BWt) for 4weeks while group 5 received Omeprazole (Omep; 20 mg/kg BWt) during terminal week. 95% Ethanol-induced ulceration followed the treatments in all except group 1. In the ...
Andrews Apraku1
Estimated H-index: 1
(Shanghai Ocean University),
Liping Liu6
Estimated H-index: 6
(Shanghai Ocean University)
+ 2 AuthorsChristian Larbi Ayisi3
Estimated H-index: 3
(Shanghai Ocean University)
Abstract Five isolipidic experimental diets (32% crude protein) were formulated to contain 3% fish oil (FO) and virgin coconut oil (3VCO) as sole lipids or blends of FO + VCO in ratios of 75:25% (0.75VCO), 50:50% (1.5VCO) and 25:75% (2.25VCO). Triplicate groups of O. niloticus were fed one of five diets to apparent satiation, twice daily for 8 weeks. It was observed that fish fed diet 3VCO exhibited the best performance with respect to feed intake (492.1 g), final weight (214.60 g) and weight ga...