Effects of anti-estrogens on bone in castrated and intact female rats
Abstract
The effects of the antiestrogens tamoxifen and keoxifene on the bone density of intact and ovariectomized female rats were determined after 4 months of therapy. The antiestrogens did not cause a decrease in bone density in intact animals, although uterine wet weight did decrease. Ovariectomy caused an increase in body weight (25%) and a significant decrease in femur density (P<0.01). Antiestrogens did not further decrease the bone density of...
Paper Details
Title
Effects of anti-estrogens on bone in castrated and intact female rats
Published Date
Oct 1, 1987
Volume
10
Issue
1
Pages
31 - 35
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