Original paper
Hydrogen Peroxide-induced Structural Alterations of RNase A
Abstract
Proteins exposed to oxidative stress are degraded via proteolytic pathways. In the present study, we undertook a series of in vitro experiments to establish a correlation between the structural changes induced by mild oxidation of the model protein RNase A and the proteolytic rate found upon exposure of the modified protein toward the isolated 20 S proteasome. Fourier transform infrared spectroscopy was used as a structure-sensitive probe. We...
Paper Details
Title
Hydrogen Peroxide-induced Structural Alterations of RNase A
Published Date
Mar 1, 2001
Volume
276
Issue
12
Pages
9492 - 9502
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History