Original paper
Widespread Genetic Heterogeneity in Multiple Myeloma: Implications for Targeted Therapy
Abstract
We performed massively parallel sequencing of paired tumor/normal samples from 203 multiple myeloma (MM) patients and identified significantly mutated genes and copy number alterations and discovered putative tumor suppressor genes by determining homozygous deletions and loss of heterozygosity. We observed frequent mutations in KRAS (particularly in previously treated patients), NRAS, BRAF, FAM46C, TP53, and DIS3 (particularly in nonhyperdiploid...
Paper Details
Title
Widespread Genetic Heterogeneity in Multiple Myeloma: Implications for Targeted Therapy
Published Date
Jan 1, 2014
Journal
Volume
25
Issue
1
Pages
91 - 101
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Notes
History