The effect of plant phenolics on the formation of 7,12-dimethylbenz[a]anthracene–DNA adducts and TPA-stimulated polymorphonuclear neutrophils chemiluminescence in vitro

Phenolics, common plant constituents, form up an important part of human diet and are considered potential chemopreventive agents. In the present study, structurally diverse phenolics, such as tannic acid, protocatechuic acid, chlorogenic acid and resveratrol, were investigated for their inhibitory effects on covalent binding of 7,12-dimethylbenz[a]anthracene (DMBA) to DNA in vitro and the suppression of oxidative burst in...