Original paper

Suppressed Proliferative Response of Spleen T Cells from Metallothionein Null Mice

Volume: 46, Issue: 2, Pages: 101 - 107
Published: Feb 1, 2002
Abstract
To investigate the role of metal‐binding protein, metallothionein (MT), in lymphocyte activation, the mitogen‐induced proliferation of freshly isolated spleen cells was compared among MT‐I, II null, and control 129/Sv mice. Spleen cells from MT null mice exhibited a markedly reduced proliferation compared with control cells when stimulated by concanavalin A or anti‐CD3(∈) mAb, but not by lipopolysaccharide, indicating that only the response of T...
Paper Details
Title
Suppressed Proliferative Response of Spleen T Cells from Metallothionein Null Mice
Published Date
Feb 1, 2002
Volume
46
Issue
2
Pages
101 - 107
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