Seiichiro Himeno
Kitasato University
25Publications
16H-index
842Citations
Publications 25
Newest
Published on Dec 1, 2006in Toxicology 3.27
Kazuo Kobayashi8
Estimated H-index: 8
(Kitasato University),
Seiichiro Himeno16
Estimated H-index: 16
(Kitasato University)
+ 4 AuthorsTatsuya Hasegawa19
Estimated H-index: 19
Metallothionein (MT) is a low-molecular-weight cysteine-rich protein which has a high affinity for metals. The synthesis of MT is induced by heavy metals such as cadmium and zinc. However, little is known about the induction of MT by tetravalent or pentavalent metals. We investigated the induction of MT synthesis by a pentavalent vanadium compound in mice. Hepatic MT concentrations were increased by subcutaneous injection of ammonium metavanadate (AMV) dose-dependently, and to the similar levels...
13 Citations Source Cite
Published on Jun 1, 2005in Journal of Cellular Physiology 3.92
Atsuko Sakurai4
Estimated H-index: 4
(Kitasato University),
Michie Nishimoto2
Estimated H-index: 2
(Kitasato University)
+ 4 AuthorsShuntaro Hara36
Estimated H-index: 36
(Kitasato University)
Thioredoxin reductase (TrxR) is a selenoprotein that catalyzes the reduction of the active site disulfide of thioredoxin (Trx), which regulates the redox status of the cells. In the present study, we found that TrxR1, one of the three TrxR isozymes, was induced by cadmium as well as tumor necrosis factor α (TNFα) in bovine arterial endothelial cells (BAEC), and investigated the mechanism of cadmium-induced TrxR1 expression. We here showed that cadmium, differently from TNFα, enhanced the promote...
128 Citations Source Cite
Published on Sep 1, 2005in Journal of Cancer Research and Clinical Oncology 3.28
Satoru Murata22
Estimated H-index: 22
(Nippon Medical School),
Hiroyuki Tajima13
Estimated H-index: 13
(Nippon Medical School)
+ 8 AuthorsMitsuo Satake15
Estimated H-index: 15
Purpose: Isolated pelvic perfusion (IPP) therapy exposes target tissues to high doses of anticancer drugs with low systemic concentrations, but the major drawback is drug leakage into the systemic circulation, which often thwarts the increased drug concentration. In this study, the efficacy of altering the in-out flow rate during IPP in order to decrease the leakage was assessed in adult pigs. Methods: The abdominal aorta and the infrarenal vena cava were occluded with two balloon catheters, blo...
13 Citations Source Cite
Published on Jan 1, 2004in Cancer Chemotherapy and Pharmacology 2.81
Yukihiro Kondo17
Estimated H-index: 17
(Nippon Medical School),
Seiichiro Himeno16
Estimated H-index: 16
(Kitasato University)
+ 3 AuthorsNobumasaimura39
Estimated H-index: 39
(Kitasato University)
Attenuation of the renal toxicity of cis-diamminedichloroplatinum (CDDP) is important in the use of this effective but cytotoxic anticancer agent. We have previously shown that the renal toxicity of CDDP can be efficiently reduced by the induction of metallothionein (MT) by preadministration of bismuth compounds in mice. Bismuth subnitrate (BSN) is used as an antigastric ulcer agent and as an antidiarrheic agent, and is suitable for inducing MT in the kidney in cancer patients. However, due to t...
26 Citations Source Cite
Published on Jan 1, 2004in Journal of Cellular Physiology 3.92
Atsuko Sakurai4
Estimated H-index: 4
(Kitasato University),
Kouji Yuasa2
Estimated H-index: 2
(Kitasato University)
+ 5 AuthorsShuntaro Hara36
Estimated H-index: 36
(Kitasato University)
Thioredoxin reductase (TrxR) is a flavoprotein that contains a C-terminal penultimate selenocysteine (Sec) and has an ability to reduce thioredoxin (Trx), which regulates the activity of NF-κB. To date, three TrxR isozymes, TrxR1, TrxR2, and TrxR3, have been identified. In the present study, we found that among these isozymes only TrxR1 was induced by tumor necrosis factor-α (TNFα) in vascular endothelial cells. Furthermore, the overexpression of TrxR1 enhanced TNFα-induced DNA-binding activity ...
58 Citations Source Cite
Published on Dec 1, 2003in The Journal of Urology 5.38
Yukihiro Kondo17
Estimated H-index: 17
(Nippon Medical School),
Kenji Yamagata2
Estimated H-index: 2
(Nippon Medical School)
+ 3 AuthorsTaiji Nishimura12
Estimated H-index: 12
(Nippon Medical School)
ABSTRACTPurpose: The metal binding protein metallothionein (MT) confers drug resistance when MT is induced in tumor tissues. Cisplatin is known to induce MT synthesis in tumor tissues, which may lead to drug resistance. We examined whether a difference in the administration schedule of cisplatin affect the efficiency of MT induction.Materials and Methods: Balb/c nude mice were inoculated with NMB-1 human bladder tumor tissues and injected with cisplatin (total dose of 64 μmol/kg) in a single inj...
3 Citations Source Cite
Published on Feb 1, 2002in Microbiology and Immunology 1.33
Masaharu Mita9
Estimated H-index: 9
(Kitasato University),
Nobumasaimura39
Estimated H-index: 39
(Kitasato University)
+ 1 AuthorsSeiichiro Himeno16
Estimated H-index: 16
(Kitasato University)
To investigate the role of metal-binding protein, metallothionein (MT), in lymphocyte activation, the mitogen-induced proliferation of freshly isolated spleen cells was compared among MT-I, II null, and control 129/Sv mice. Spleen cells from MT null mice exhibited a markedly reduced proliferation compared with control cells when stimulated by concanavalin A or anti-CD3(∈) mAb, but not by lipopolysaccharide, indicating that only the response of T cells to mitogens was suppressed in MT null mice. ...
12 Citations Source Cite
Published on Jan 1, 2002in Journal of Inorganic Biochemistry 3.06
Seiichiro Himeno16
Estimated H-index: 16
(Kitasato University)
Metallothionein (MT) is an important factor for cadmium resistance in mammalian cells. Most Cd-resistant cell lines thus far established have shown enhanced production of MT protein. However, the presence of high concentrations of MT, which traps cellular cadmium ions efficiently, has hindered the investigation of cadmium transport in Cd-resistant cells. Utilization of MT null mice or cultured cells derived from MT null mice is a useful way to isolate and characterize non-MT factor(s) for Cd res...
14 Citations Source Cite
Published on Jan 1, 2002in Tohoku Journal of Experimental Medicine 1.42
Seiichiro Himeno16
Estimated H-index: 16
(Kitasato University),
Takahiro Yanagiya7
Estimated H-index: 7
+ 2 AuthorsNobumasaimura39
Estimated H-index: 39
(Kitasato University)
29 Citations Source Cite
Published on Jan 1, 2001in Biological & Pharmaceutical Bulletin 1.69
Shuntaro Hara36
Estimated H-index: 36
(Kitasato University),
Yasuko Shoji2
Estimated H-index: 2
(Kitasato University)
+ 3 AuthorsNobumasaimura39
Estimated H-index: 39
(Kitasato University)
Damage to the vascular endothelium by reactive oxygen species causes many cardiovascular diseases including atherosclerosis. Such damage can be prevented by selenium (Se), which is thought to exert its actions mainly through the expression of selenoproteins. Se deficiency increased the susceptibility to tert-butylhydroperoxide (t-BuOOH) and enhanced lipid peroxidation in bovine arterial endothelial cells (BAEC). We investigated the effects of Se deficiency on the expression of the selenoproteins...
45 Citations Source Cite
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