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Rigidity, secondary structure, and the universality of the boson peak in proteins.

Published on Jun 1, 2014in Biophysical Journal3.665
· DOI :10.1016/j.bpj.2014.05.009
Stefania Perticaroli15
Estimated H-index: 15
(UT: University of Tennessee),
Jonathan D. Nickels18
Estimated H-index: 18
(UT: University of Tennessee)
+ 1 AuthorsAlexei P. Sokolov49
Estimated H-index: 49
(UT: University of Tennessee)
Sources
Abstract
Complementary neutron- and light-scattering results on nine proteins and amino acids reveal the role of rigidity and secondary structure in determining the time- and lengthscales of low-frequency collective vibrational dynamics in proteins. These dynamics manifest in a spectral feature, known as the boson peak (BP), which is common to all disordered materials. We demonstrate that BP position scales systematically with structural motifs, reflecting local rigidity: disordered proteins appear softer than α-helical proteins; which are softer than β-sheet proteins. Our analysis also reveals a universal spectral shape of the BP in proteins and amino acid mixtures; superimposable on the shape observed in typical glasses. Uniformity in the underlying physical mechanism, independent of the specific chemical composition, connects the BP vibrations to nanometer-scale heterogeneities, providing an experimental benchmark for coarse-grained simulations, structure/rigidity relationships, and engineering of proteins for novel applications.
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