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Rigidity, secondary structure, and the universality of the boson peak in proteins.

Published on Jun 1, 2014in Biophysical Journal3.67
· DOI :10.1016/j.bpj.2014.05.009
Stefania Perticaroli13
Estimated H-index: 13
(UT: University of Tennessee),
Jonathan D. Nickels16
Estimated H-index: 16
(UT: University of Tennessee)
+ 1 AuthorsAlexei P. Sokolov48
Estimated H-index: 48
(UT: University of Tennessee)
Abstract
Complementary neutron- and light-scattering results on nine proteins and amino acids reveal the role of rigidity and secondary structure in determining the time- and lengthscales of low-frequency collective vibrational dynamics in proteins. These dynamics manifest in a spectral feature, known as the boson peak (BP), which is common to all disordered materials. We demonstrate that BP position scales systematically with structural motifs, reflecting local rigidity: disordered proteins appear softer than α-helical proteins; which are softer than β-sheet proteins. Our analysis also reveals a universal spectral shape of the BP in proteins and amino acid mixtures; superimposable on the shape observed in typical glasses. Uniformity in the underlying physical mechanism, independent of the specific chemical composition, connects the BP vibrations to nanometer-scale heterogeneities, providing an experimental benchmark for coarse-grained simulations, structure/rigidity relationships, and engineering of proteins for novel applications.
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  • References (64)
  • Citations (25)
References64
Newest
#1Jonathan D. Nickels (UT: University of Tennessee)H-Index: 16
#2Stefania Perticaroli (UT: University of Tennessee)H-Index: 13
Last.Alexei P. Sokolov (UT: University of Tennessee)H-Index: 48
view all 6 authors...
#1Stefania Perticaroli (UT: University of Tennessee)H-Index: 13
#2Jonathan D. Nickels (ORNL: Oak Ridge National Laboratory)H-Index: 16
Last.Alexei P. Sokolov (UT: University of Tennessee)H-Index: 48
view all 6 authors...
#1Jonathan D. Nickels (UT: University of Tennessee)H-Index: 16
#2Hugh O’Neill (UT: University of Tennessee)H-Index: 17
Last.Jeremy C. Smith (UT: University of Tennessee)H-Index: 53
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#1Sam Hay (University of Manchester)H-Index: 23
#2Nigel S. Scrutton (University of Manchester)H-Index: 49
#1Georg Ehlers (ORNL: Oak Ridge National Laboratory)H-Index: 24
#2A. Podlesnyak (ORNL: Oak Ridge National Laboratory)H-Index: 18
Last.Paul E. Sokol (IU: Indiana University Bloomington)H-Index: 19
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#2Nan K. Li (NCSU: North Carolina State University)H-Index: 10
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#2Yasumasa JotiH-Index: 20
Last.Mikio Kataoka (Nara Institute of Science and Technology)H-Index: 42
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#1Tatiana Starciuc (Lille University of Science and Technology)H-Index: 1
#2Nicolas Tabary (Lille University of Science and Technology)H-Index: 14
Last.Alain Hédoux (Lille University of Science and Technology)H-Index: 24
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#1Konstantin Motovilov (MIPT: Moscow Institute of Physics and Technology)H-Index: 2
#2V. Grinenko (TUD: Dresden University of Technology)H-Index: 9
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#1Mariana F. Ando (FSU: University of Jena)H-Index: 1
#2Omar Benzine (FSU: University of Jena)H-Index: 3
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#1Ana Tinoco (University of Minho)H-Index: 1
#2J. Gonçalves (University of Minho)
Last.Artur Ribeiro (University of Minho)H-Index: 10
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