Original paper
Lipidomics and genomics of Mycobacterium tuberculosis reveal lineage‐specific trends in mycolic acid biosynthesis
Abstract
Mycolic acids (MAs) are α-alkyl, β-hydroxy long-chain fatty acids found in abundance in the cell envelope of the Mycobacterium tuberculosis complex (MTBC). MAs form an efficient permeability barrier, modulate host innate immune responses, and are the targets of several anti-tuberculosis drugs. Using mass spectrometry, we measured the relative abundance of 80 MA species across 36 clinical isolates of MTBC covering four major phylogenetic...
Paper Details
Title
Lipidomics and genomics of Mycobacterium tuberculosis reveal lineage‐specific trends in mycolic acid biosynthesis
Published Date
Sep 19, 2014
Journal
Volume
3
Issue
6
Pages
823 - 835
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Notes
History