Original paper
Mechanisms of oleic acid deterioration in insulin secretion: Role in the pathogenesis of type 2 diabetes
Abstract
Obesity is highly associated with type 2 diabetes where free fatty acids (FFAs) may be a trigger factor. To examine this hypothesis, in this study, we investigated the role of FFAs in the pathogenic development of type 2 diabetes. The release of insulin, the expression of preproinsulin (PPI), glucose transporter2 (GLUT2) and pancreatic duodenal homeobox-1 (PDX-1), and levels of intracellular free Ca++([Ca++]i) were measured in rat pancreatic...
Paper Details
Title
Mechanisms of oleic acid deterioration in insulin secretion: Role in the pathogenesis of type 2 diabetes
Published Date
Sep 1, 2005
Journal
Volume
77
Issue
17
Pages
2071 - 2081
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Notes
History