Increased oxidative stress precedes the onset of high-fat diet–induced insulin resistance and obesity
Abstract
Insulin resistance is a key pathophysiological feature of metabolic syndrome. However, the initial events triggering the development of insulin resistance and its causal relations with dysregulation of glucose and fatty acids metabolism remain unclear. We investigated biological pathways that have the potential to induce insulin resistance in mice fed a high-fat diet (HFD). We demonstrate that the pathways for reactive oxygen species (ROS)...
Paper Details
Title
Increased oxidative stress precedes the onset of high-fat diet–induced insulin resistance and obesity
Published Date
Aug 1, 2008
Journal
Volume
57
Issue
8
Pages
1071 - 1077
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