Original paper
Adenosine is required for sustained inflammasome activation via the A2A receptor and the HIF-1α pathway
Abstract
Inflammasome pathways are important in chronic diseases; however, it is not known how the signalling is sustained after initiation. Inflammasome activation is dependent on stimuli such as lipopolysaccharide (LPS) and ATP that provide two distinct signals resulting in rapid production of interleukin (IL)-1β, with the lack of response to repeat stimulation. Here we report that adenosine is a key regulator of inflammasome activity, increasing the...
Paper Details
Title
Adenosine is required for sustained inflammasome activation via the A2A receptor and the HIF-1α pathway
Published Date
Dec 19, 2013
Journal
Volume
4
Issue
1
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Notes
History