Phosphorylation of GATA-4 Is Involved in α1-Adrenergic Agonist-responsive Transcription of the Endothelin-1 Gene in Cardiac Myocytes

The expression of endothelin-1 (ET-1) in cardiac myocytes is markedly induced during the development of heart failurein vivo and by stimulation with the α1-adrenergic agonist phenylephrine in culture. Although recent studies have suggested a role for cardiac-specific zinc finger GATA factors in the transcriptional pathways that modulate cardiac hypertrophy, it is unknown whether these factors are also involved in cardiac ET-1 transcription and...