Review paper
Multivariate modelling to study the effect of the manufacturing process on the complete tablet dissolution profile
Volume: 486, Issue: 1-2, Pages: 112 - 120
Published: May 1, 2015
Abstract
Dissolution is invariably identified as a critical quality attribute for oral solid dosage forms, since it is related to when a drug is available for absorption and ultimately exert its effect. In this paper, the influence of granule and compression variability introduced by a design of experiments on the entire dissolution profile was studied with an innovative multivariate tool: bi-directional projections to orthogonal structures (O2PLS). This...
Paper Details
Title
Multivariate modelling to study the effect of the manufacturing process on the complete tablet dissolution profile
Published Date
May 1, 2015
Volume
486
Issue
1-2
Pages
112 - 120
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